Acute liver failure as the first manifestation of very late relapsing of Hodgkin’s disease

  • Xavier Ortín | xavi.ortin@gmail.com
  • Marta Rodríguez-Luaces
  • Ramon Bosch
  • Marylene Lejeune
  • Llorenç Font

Abstract

Hodgkin’s disease is, in general, a lymph node-based disease. It usually starts in an area within the lymphatic system and spreads, in an orderly manner, along the lymph­atic chain to contiguous lymph node areas. There have been sporadic case reports of acute liver failure caused by hematological malignancies. Generally, liver failure is a feature of stage IV end-stage disease, when it occurs in lymphoma. Thus, hepatic involvement usually occurs late in the course of Hodgkin’s disease or with advanced-stage disease, and primary presentation in the liver with acute liver failure is extremely rare. In most cases, the diagnosis was made at aut­opsy. We describe a patient with Hodgkin’s disease presenting with acute liver failure. This is a very unusual Hodgkin’s disease form of presentation, because the acute liver failure was the presenting feature of the disease. Furthermore, the lymphoma occurred as a very late relapse, twenty years after the first diagnosis. To the best of our knowledge, such a case has not been described to date.

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Author Biographies

Xavier Ortín
Servicio de Hematología. Hospital de Tortosa Verge de la Cinta. Tortosa. Spain
Marta Rodríguez-Luaces
Servicio de Hematología. Hospital de Tortosa Verge de la Cinta. Tortosa. Spain
Ramon Bosch
Servicio de Anatomía Patológica. Hospital de Tortosa Verge de la Cinta. Tortosa. Spain
Marylene Lejeune
Servicio de Anatomía Patológica. Hospital de Tortosa Verge de la Cinta. Tortosa. Spain
Llorenç Font
Servicio de Hematología. Hospital de Tortosa Verge de la Cinta. Tortosa. Spain
Published
2010-07-23
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Case Reports
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How to Cite
Ortín, X., Rodríguez-Luaces, M., Bosch, R., Lejeune, M., & Font, L. (2010). Acute liver failure as the first manifestation of very late relapsing of Hodgkin’s disease. Hematology Reports, 2(1), e5. https://doi.org/10.4081/hr.2010.e5