Acute liver failure as the first manifestation of very late relapsing of Hodgkin’s disease

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Xavier Ortín *
Marta Rodríguez-Luaces
Ramon Bosch
Marylene Lejeune
Llorenç Font
(*) Corresponding Author:
Xavier Ortín | xavi.ortin@gmail.com

Abstract

Hodgkin’s disease is, in general, a lymph node-based disease. It usually starts in an area within the lymphatic system and spreads, in an orderly manner, along the lymph­atic chain to contiguous lymph node areas. There have been sporadic case reports of acute liver failure caused by hematological malignancies. Generally, liver failure is a feature of stage IV end-stage disease, when it occurs in lymphoma. Thus, hepatic involvement usually occurs late in the course of Hodgkin’s disease or with advanced-stage disease, and primary presentation in the liver with acute liver failure is extremely rare. In most cases, the diagnosis was made at aut­opsy. We describe a patient with Hodgkin’s disease presenting with acute liver failure. This is a very unusual Hodgkin’s disease form of presentation, because the acute liver failure was the presenting feature of the disease. Furthermore, the lymphoma occurred as a very late relapse, twenty years after the first diagnosis. To the best of our knowledge, such a case has not been described to date.

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Author Biographies

Xavier Ortín

Servicio de Hematología. Hospital de Tortosa Verge de la Cinta. Tortosa. Spain

Marta Rodríguez-Luaces

Servicio de Hematología. Hospital de Tortosa Verge de la Cinta. Tortosa. Spain

Ramon Bosch

Servicio de Anatomía Patológica. Hospital de Tortosa Verge de la Cinta. Tortosa. Spain

Marylene Lejeune

Servicio de Anatomía Patológica. Hospital de Tortosa Verge de la Cinta. Tortosa. Spain

Llorenç Font

Servicio de Hematología. Hospital de Tortosa Verge de la Cinta. Tortosa. Spain