A case of cutaneous large B-cell lymphoma of the legs appearing as chronic venous ulceration

  • Marta Carlesimo | marta.carlesimo@uniroma1.it Dermatology Unit, S.Andrea Hospital, Faculty of Medicine and Psichology, University of Rome La Sapienza, Italy.
  • Diego Orsini Dermatology Unit, S.Andrea Hospital, Faculty of Medicine and Psichology, University of Rome La Sapienza, Italy.
  • Alessanrdra Narcisi Dermatology Unit, S.Andrea Hospital, Faculty of Medicine and Psichology, University of Rome La Sapienza, Italy.
  • Claudia Abruzzese Dermatology Unit, S.Andrea Hospital, Faculty of Medicine and Psichology, University of Rome La Sapienza, Italy.
  • Giorgia Cortesi Dermatology Unit, S.Andrea Hospital, Faculty of Medicine and Psichology, University of Rome La Sapienza, Italy.
  • Gabriella De Marco Dermatology Unit, S.Andrea Hospital, Faculty of Medicine and Psichology, University of Rome La Sapienza, Italy.
  • Alfredo Rossi Dermatology Unit, S.Andrea Hospital, Faculty of Medicine and Psichology, University of Rome La Sapienza, Italy.

Abstract

We report here a case of a woman with a cutaneous large B-cell lymphoma of the legs. She had a plaque lesion, superficially ulcerated and necrotized with tumorous borders situated on the posterior side of the right leg and two red or bluish-red nodular lesions. A skin biopsy from both nodular and plaque lesion showed a diffuse infiltrate of atypical large B cells CD20+ and CD79a+, spanning epidermis, dermis and subcutaneous tissue. A therapeutic approach containing anti-CD20 monoclonal antibody (rituximab) was suggested.

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Published
2012-04-24
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Section
Case Reports
Keywords:
Primary cutaneous B cell lymphoma, B cell lymphoma of the leg, Immunophenotype, Therapy
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How to Cite
Carlesimo, M., Orsini, D., Narcisi, A., Abruzzese, C., Cortesi, G., De Marco, G., & Rossi, A. (2012). A case of cutaneous large B-cell lymphoma of the legs appearing as chronic venous ulceration. Hematology Reports, 4(2), e6. https://doi.org/10.4081/hr.2012.e6