Pneumothorax in an early phase after allogeneic hematopoietic stem cell transplantation

  • Yasuhiro Ebihara | ebihara@ims.u-tokyo.ac.jp Department of Pediatric Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Japan.
  • Shohei Yamamoto Department of Pediatric Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Japan.
  • Shinji Mochizuki Division of Stem Cell Processing, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Japan.
  • Masao Tsukada Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Japan.
  • Yuki Taya Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Japan.
  • Toshiro Kawakita Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Japan.
  • Seiko Kato Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Japan.
  • Jun Ooi Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Japan.
  • Satoshi Takahashi Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Japan.
  • Arinobu Tojo Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Japan.
  • Kohichiro Tsuji Department of Pediatric Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo; Division of Stem Cell Processing, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo; Department of Pediatrics, Shinshu Ueda Medical Center, Japan.

Abstract

Pneumothorax is very rare after early phase of hematopoietic stem cell transplantation (HSCT) and usually accompanied with pulmonary chronic graft-versus-host disease (GVHD), such as bronchiolitis obliterans and bronchiolitis obliterans organizing pneumonia. The present study describes the case of a seventeen-year-old male diagnosed with acute myeloid leukemia who underwent allogeneic bone marrow transplantation (BMT). Pneumothorax occurred at day 43 after BMT. Pneumothorax occurred in early phase of HSCT is extremely rare. The early onset of acute GVHD and the entity of cytomegalovirus might worsen the pulmonary tissue damages for the onset of pneumothorax, indicating that we should be aware of the possibility to occur pneumothorax even in the early period after allogeneic HSCT.

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Published
2013-06-28
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Section
Case Reports
Keywords:
pneumothorax, air-leak syndrome, allogeneic hematopoietic stem cell transplantation
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How to Cite
Ebihara, Y., Yamamoto, S., Mochizuki, S., Tsukada, M., Taya, Y., Kawakita, T., Kato, S., Ooi, J., Takahashi, S., Tojo, A., & Tsuji, K. (2013). Pneumothorax in an early phase after allogeneic hematopoietic stem cell transplantation. Hematology Reports, 5(2), e10. https://doi.org/10.4081/hr.2013.e10