A case of acute promyelocytic leukemia with morphologic multilineage dysplastic changes

  • Setsuki Isono Clinical Laboratory, Kakogawa West City Hospital, Japan.
  • Katsuyasu Saigo | ksaigo@himeji-du.ac.jp Faculty of Pharmacological Sciences, Himeji Dokkyo University, Japan.
  • Keiko Nagata Clinical Laboratory, Kakogawa West City Hospital, Japan.
  • Keiko Numata Clinical Laboratory, Kakogawa West City Hospital, Japan.
  • Toshiaki Kojitani Clinical Laboratory, Kakogawa West City Hospital, Japan.
  • Akiharu Okamura Section of Pathology, Kakogawa West City Hospital, Japan.
  • Akihiko Nishizawa Section of Internal Medicine, Kakogawa West City Hospital, Japan.
  • Masafumi Takata Faculty of Pharmacological Sciences, Himeji Dokkyo University, Japan.
  • Mariko Takenokuchi Section of Internal Medicine, Kakogawa West City Hospital, Japan.
  • Eiji Tatsumi Department of Nutrition and Health, Sagami Women’s University, Japan.

Abstract

Although reports of typical acute promyelocytic leukemia (APL) cases rarely mention dysplastic changes, this report concerns a rare case of APL with tri-lineage dysplastic changes resembling the characteristic features of myelodysplastic syndrome (MDS). The patient, a 77-year-old Japanese male, was diagnosed as having pancytopenia with hematologic morphological abnormalities comprising micromegakaryocytes, neutrophils with hypo-granulation and negative peroxidase activity, and erythroblasts containing nuclei with abnormalities such as karyorrhexis. Although there is one report of a case of transformation of de novo MDS into APL and several reports of cases of therapy-related MDS transformed into APL, our patient had no history of cytopenia or of either chemo or radiation therapy. Our case can thus be considered to constitute a rare case of APL with dysplastic morphology.

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Published
2013-02-15
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Section
Case Reports
Keywords:
acute promyelocytic leukemia, dysplasia, all-trans retinoic acid
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How to Cite
Isono, S., Saigo, K., Nagata, K., Numata, K., Kojitani, T., Okamura, A., Nishizawa, A., Takata, M., Takenokuchi, M., & Tatsumi, E. (2013). A case of acute promyelocytic leukemia with morphologic multilineage dysplastic changes. Hematology Reports, 5(1), e5. https://doi.org/10.4081/hr.2013.e5