Kinetics of HIV-1 in cerebrospinal fluid and plasma in cryptococcal meningitis

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Diego M. Cecchini *
Ana M. Cañizal
Haroldo Rojas
Alicia Arechavala
Ricardo Negroni
María B. Bouzas
Jorge A. Benetucci
(*) Corresponding Author:
Diego M. Cecchini | diegocec@gmail.com

Abstract

In order to determine HIV-1 kinetics in cerebrospinal fluid (CSF) and plasma in patients with cryptococcal meningitis (CM), we undertook a prospective collection of paired CSF/plasma samples from antiretroviral therapy- free HIV-infected patients with CM. Samples were obtained at baseline (S1) and at the second (S2) and third (S3) weeks of antifungal therapy. HIV-1 CSF concentrations were significantly lower in both S2 and S3 with respect to S1. Plasma concentrations remained stable. HIV-1 concentrations were higher in plasma than CSF in all cases. Patients who survived the episode of CM (but not those who died) showed a decrease in CSF viral load, what suggests different viral kinetics of HIV-1 in the CSF according to the clinical course of this opportunistic disease.

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