Advances in rapid identification and susceptibility testing of bacteria in the clinical microbiology laboratory: implications for patient care and antimicrobial stewardship programs

  • Florian P. Maurer Institute of Medical Microbiology, Virology and Hygiene, Hamburg; Antibiotic Stewardship Team, University Medical Centre Hamburg Eppendorf, Hamburg, Germany.
  • Martin Christner Institute of Medical Microbiology, Virology and Hygiene, Hamburg, Germany.
  • Moritz Hentschke MVZ Labor Dr. Fenner und Kollegen, Hamburg, Germany.
  • Holger Rohde | rohde@uke.de Institute of Medical Microbiology, Virology and Hygiene, Hamburg, Germany.

Abstract

Early availability of information on bacterial pathogens and their antimicrobial susceptibility is of key importance for the management of infectious diseases patients. Currently, using traditional approaches, it usually takes at least 48 hours for identification and susceptibility testing of bacterial pathogens. Therefore, the slowness of diagnostic procedures drives prolongation of empiric, potentially inappropriate, antibacterial therapies. Over the last couple of years, the improvement of available techniques (e.g. for susceptibility testing, DNA amplification assays), and introduction of novel technologies (e.g. MALDI-TOF) has fundamentally changed approaches towards pathogen identification and characterization. Importantly, these techniques offer increased diagnostic resolution while at the same time shorten the time-to-result, and are thus of obvious importance for antimicrobial stewardship. In this review, we will discuss recent advances in medical microbiology with special emphasis on the impact of novel techniques on antimicrobial stewardship programs.

Downloads

Download data is not yet available.

PlumX Metrics

PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

Published
2017-03-30
Keywords:
Rapid diagnostics, MALDI-ToF, PCR, rapid susceptibility testing
Statistics
Abstract views: 2634

PDF: 905
HTML: 1468
Share it
How to Cite
Maurer, F., Christner, M., Hentschke, M., & Rohde, H. (2017). Advances in rapid identification and susceptibility testing of bacteria in the clinical microbiology laboratory: implications for patient care and antimicrobial stewardship programs. Infectious Disease Reports, 9(1). https://doi.org/10.4081/idr.2017.6839