Five generations of cell preparation: a translational framework for categorizing regenerative stem cell therapies

  • Christy L. Hunt Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, United States.
  • Yeng F. Her Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN; Mayo Clinic Medical Scientist Training Program, Mayo Clinic College of Medicine, Rochester, MN, United States.
  • Luke A. Law Department of Anesthesiology, Mayo Clinic, Rochester, MN, United States.
  • Mohamad Bydon Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United States.
  • Ahmad Nassr Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, United States.
  • Jay Smith Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, United States.
  • William D. Mauck Department of Anesthesiology, Mayo Clinic, Rochester, MN, United States.
  • Jason S. Eldrige Department of Physical Medicine and Rehabilitation, Mayo Clinic, Jacksonville, FL, United States.
  • Gerard A. Malanga Department of Physical Medicine and Rehabilitation, Rutgers School of Medicine, Newark, NJ, United States.
  • Wenchun Qu | qu.wenchun@mayo.edu Department of Anesthesiology, Department of Neurologic Surgery, and Spine Center, Mayo Clinic, Rochester, MN, United States.

Abstract

A description of a proposed categorization scheme of regenerative stem cell therapies illustrated by review of basic science and clinical studies involving the clinical application of mesenchymal stem cells (MSCs) is proposed. The aim of this review is to provide a novel framework for categorizing MSCs according to preparation strategy. Selected basic science studies and clinical trials were used to illustrate the applications in each category of stem cells. A review of the literature regarding stem cell sources and preparation makes apparent that there are five generations of stem cells in various states of study and clinical application, ranging from therapies currently being used in officebased practice to stem cell generations that hold considerable promise but with persistent concerns regarding safety and feasibility. In the last decade, stem cell research has spread to many different branches of regenerative medicine. Basic science and clinical studies examining the use of stem cell transplantation in the treatment of a wide range of human diseases have exponentially increased. The Five Generations Model may be a helpful way to describe stem cells in research and in clinical application. Describing stem cells in terms of cell preparation strategy, rather than source, may facilitate a greater understanding of this therapy by physicians and patients, and provides an opportunity for researchers to incorporate this helpful framework into a description of their background and findings.

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Published
2017-06-15
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Section
Reviews
Keywords:
mesenchymal stem cells, stromal cells, regenerative medicine, bone marrow derived stem cells, adipose derived stem cells
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How to Cite
Hunt, C., Her, Y., Law, L., Bydon, M., Nassr, A., Smith, J., Mauck, W., Eldrige, J., Malanga, G., & Qu, W. (2017). Five generations of cell preparation: a translational framework for categorizing regenerative stem cell therapies. Journal of the American Academy of Regenerative Medicine, 1(1). https://doi.org/10.4081/jaarm.2017.7239

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