Prosthesis infections after orthopedic joint replacement: the possible role of bacterial biofilms

  • Zhijun Song | songzj95@gmail.com Department of Orthopedic Surgery, Frederiksberg University Hospital, Frederiksberg; Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
  • Lotte Borgwardt Department of Orthopedic Surgery, Frederiksberg University Hospital, Frederiksberg, Denmark.
  • Niels Høiby Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
  • Hong Wu Department of Clinical Microbiology, Rigshospitalet, Copenhagen; The Singapore Centre on Environmental Life Sciences Engineering, Nanyang Technological University, Singapore.
  • Torben Sandberg Sørensen Department of Orthopedic Surgery, Frederiksberg University Hospital, Frederiksberg, Denmark.
  • Arne Borgwardt Department of Orthopedic Surgery, Frederiksberg University Hospital, Frederiksberg, Denmark.

Abstract

Prosthesis-related infection is a serious complication for patients after orthopedic joint replacement, which is currently difficult to treat with antibiotic therapy. Consequently, in most cases, removal of the infected prosthesis is the only solution to cure the infection. It is, therefore, important to understand the comprehensive interaction between the microbiological situation and the host immune responses that lead to prosthesis infections. Evidence indicates that prosthesis infections are actually biofilm-correlated infections that are highly resistant to antibiotic treatment and the host immune responses. The authors reviewed the related literature in the context of their clinical experience, and discussed the possible etiology and mechanism leading to the infections, especially problems related to bacterial biofilm, and prophylaxis and treatment of infection, including both microbiological and surgical measures. Recent progress in research into bacterial biofilm and possible future treatment options of prosthesis-related infections are discussed.

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Published
2013-06-14
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Section
Reviews
Keywords:
prosthesis-related infections, biofilms, diagnosis, prevention and control
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How to Cite
Song, Z., Borgwardt, L., Høiby, N., Wu, H., Sørensen, T. S., & Borgwardt, A. (2013). Prosthesis infections after orthopedic joint replacement: the possible role of bacterial biofilms. Orthopedic Reviews, 5(2), e14. https://doi.org/10.4081/or.2013.e14