Overview of methicillin resistant Staphylococcus aureus mediated bone and joint infections in India

  • Ram Prabhoo Department of Orthopedic Surgery, Mukund Hospital Mumbai, Maharashtra, India.
  • Ram Chaddha Department of Orthopedic and Spine Surgery, Apollo Hospitals, Navi Mumbai, Maharashtra, India.
  • Rajagopalan Iyer Department of Orthopedics; Pondicherry Institute of Medical Sciences, Puducherry, India.
  • Apurv Mehra Department of Orthopedic Surgery, Vidya Jeevan Orthopedics Super Specialty Centre, New Delhi, India.
  • Jaishid Ahdal | jahdal@wockhardt.com Department of Medical Affairs, Wockhardt Ltd, Wockhardt Towers, Bandra Kuerla Complex, G Block BKC, Bandra Kurla Complex, Bandra East, Mumbai, India.
  • Rishi Jain Department of Medical Affairs, Wockhardt Ltd, Wockhardt Towers, Bandra Kuerla Complex, G Block BKC, Bandra Kurla Complex, Bandra East, Mumbai, India.

Abstract

Staphylococcus aureus is the most common pathogen causing bone and joint infections (BJI). In India, prevalence of Methicillin resistant Staphylococcus aureus (MRSA) is increasing at an alarming rate and emerged as an important contributor towards the difficult to treat BJI. Currently available anti-MRSA agents have their own limitations with regards to reduced susceptibility as well as safety and tolerability. Furthermore, biofilms over the prosthesis with invariably multi-drug resistant strains leads to complex treatment processes. This necessitates the need to develop and screen new antibiotics against MRSA that can easily penetrate the deep pockets of infection and take care of the challenges discussed. This review aims to discuss on MRSA infection in bone and joint infection, current antibiotic regimen, its associated limitations, and finally, the need to develop new antibiotic therapy for effective management of patients with BJI.

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Published
2019-06-20
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Section
Reviews
Keywords:
Methicillin resistant S.aureus, Bone and joint infection, Biofilms, Newer anti-MRSA agents
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How to Cite
Prabhoo, R., Chaddha, R., Iyer, R., Mehra, A., Ahdal, J., & Jain, R. (2019). Overview of methicillin resistant Staphylococcus aureus mediated bone and joint infections in India. Orthopedic Reviews, 11(2). https://doi.org/10.4081/or.2019.8070