The role of adipose derived stem cells in the treatment of rotator cuff tears: from basic science to clinical application

  • Fabrizio Mocini | fabriziomocini90@gmail.com Orthopaedic Institute, Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy.
  • Andrea Stefano Monteleone Orthopaedic Institute, Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy.
  • Piero Piazza Orthopaedic Institute, Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy.
  • Valentina Cardona Orthopaedic Institute, Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy.
  • Valeria Vismara Orthopaedic Institute, Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy.
  • Piermarco Messinese Orthopaedic Institute, Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy.
  • Vincenzo Campana Orthopaedic Institute, Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy.
  • Giuseppe Sircana Orthopaedic Institute, Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy.
  • Giulio Maccauro Orthopaedic Institute, Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy.
  • Maristella Francesca Saccomanno Orthopaedic Institute, Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy.

Abstract

Over the last decade, regenerative medicine has become increasingly popular throughout the scientific community. The poor healing capacity at the tendon-bone interface makes the rotator cuff an appealing target for biologic agents. Adipose derived stem cells are mesenchymal cells with the capacity for self-renewal and multipotential differentiation. They have been recently proposed, both in isolation and as adjuvants to existing surgical therapies, for the treatment of rotator cuff tears. Several studies have been carried out in this research field, starting from the biological characteristics of adipose derived stem cells, their preparation and culture, up to the application in the experimental field on animal models and on humans. The purpose of this study was to provide a state of the art about the current basic science and clinical literature for the effectiveness of adipose derived stem cells in the treatment of rotator cuff tears.

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Published
2020-06-26
Keywords:
Rotator Cuff Tears, Adipose derived stem cells, Regenerative medicine.
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How to Cite
Mocini, F., Monteleone, A. S., Piazza, P., Cardona, V., Vismara, V., Messinese, P., Campana, V., Sircana, G., Maccauro, G., & Saccomanno, M. F. (2020). The role of adipose derived stem cells in the treatment of rotator cuff tears: from basic science to clinical application. Orthopedic Reviews, 12(1s). https://doi.org/10.4081/or.2020.8682