Oxidative stress and anabolic hormones in back pain: Current concept and preliminary analysis in male cohort

  • Edoardo Vergani Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Carmine Bruno Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Andrea Silvestrini Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome; Dipartimento di Scienze Biotecnologiche di base, cliniche intensivologiche e peri-operatorie, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Elisabetta Meucci Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome; Dipartimento di Scienze Biotecnologiche di base, cliniche intensivologiche e peri-operatorie, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Luca Proietti Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome; Dipartimento di Scienze geriatriche e ortopediche, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Andrea Perna Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome; Dipartimento di Scienze geriatriche e ortopediche, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Francesco Ciro Tamburrelli Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome; Dipartimento di Scienze geriatriche e ortopediche, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Antonio Mancini Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Abstract

Back Pain (BP) is a common medical problem; anabolic hormones, through the modulation of oxidative stress (OS), could influence fracture risk. We evaluated the prevalence of anabolic hormonal deficiencies and their relationship with OS in males with BP, associated or not to nontraumatic fractures. 49 males with BP, from 36 to 80 years, were divided in two groups according to radiological evidence of nontraumatic fractures; group A (n=25): non-fractured; group B (n=24): fractured. A different prevalence of hormonal deficits was observed: 24% of hypotestosteronemia in A, 0% in B; 16% of GHD in A, 29% in B; Total Antioxidant Capacity (TAC) showed a trend toward higher levels in B. In A, despite lower TAC, a significant inverse correlation was present between TAC and IGF-1. A greater prevalence of GHD in patients with vertebral fractures was seen and, in a subgroup, OS could mediate the deleterious effects of hyposecretory GH state.

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Published
2020-06-26
Keywords:
Back Pain, Fractures, GH deficiency, Hypogonadism, Antioxidants.
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How to Cite
Vergani, E., Bruno, C., Silvestrini, A., Meucci, E., Proietti, L., Perna, A., Tamburrelli, F. C., & Mancini, A. (2020). Oxidative stress and anabolic hormones in back pain: Current concept and preliminary analysis in male cohort. Orthopedic Reviews, 12(1s). https://doi.org/10.4081/or.2020.8686