Evaluation of antidepressant-like effect Lavandulifolia stachys in the forced swimming test in comparison with imipramine and fluoxetine

  • Shirali Kharamin Yasuj University of Medical Sciences, Yasuj, Iran, Islamic Republic of.
  • Saeed Razmeh | srazmeh@yahoo.com Yasuj University of Medical Sciences, Yasuj, Iran, Islamic Republic of.
  • Mona Nabovvati Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of.
  • Karim Moradian Kermanshah University of Medical Sciences, Kermanshah, Iran, Islamic Republic of.
  • Samaneh Rahimi Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of.
  • Maryam Orooji Alborz University of Medical Sciences, Alborz, Iran, Islamic Republic of.
  • Laleh Taghavian Yasuj University of Medical Sciences, Yasuj, Iran, Islamic Republic of.
  • Majid Kherad Mand Maher University of Social Welfare and Rehabilitation Sciences, Tehran, Iran, Islamic Republic of.

Abstract

Depression is a global problem associated with multiple social and health issues. In the present study, we analyzed the antidepressant effects of Lavandulifolia stachys, an herbal planton forced swimming test (FST). In this study, 36 rats were used. We gavaged the aqueous extract of plant (50, 100, 150 mg/kg), imipramine and fluoxetine (20 mg/kg) as standard antidepressant drug and normal saline for control group for a week. Then, their behavioral responses including climbing, swimming and immobility were recorded during the 5-min FST. Our experiments showed significant effects of Lavandulifolia stachys on swimming and immobility but not effect on climbing behaviors. Imipramine and fluoxetine increased climbing and swimming, respectively, and both reduced immobility, compared to saline control. Finally, our results show the extract of Lavandulifolia stachys could play an important role in treatment of depression like fluoxetine.

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Published
2019-06-12
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Keywords:
Lavandulifolia stachys, Fluoxetine, Imipramine, depression, forced swimming test
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How to Cite
Kharamin, S., Razmeh, S., Nabovvati, M., Moradian, K., Rahimi, S., Orooji, M., Taghavian, L., & Mand Maher, M. (2019). Evaluation of antidepressant-like effect Lavandulifolia stachys in the forced swimming test in comparison with imipramine and fluoxetine. International Journal of Plant Biology, 10(1). https://doi.org/10.4081/pb.2019.7458

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