B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemia

  • Annelieke A.A. van der Linde Department of Pediatrics, Jeroen Bosch Hospital, ‘s-Hertogenbosch, Netherlands.
  • Ellen J.H. Schatorjé Department of Pediatrics, Jeroen Bosch Hospital, ‘s-Hertogenbosch, Netherlands.
  • Annemieke M. van der Weij Department of Pediatrics, Jeroen Bosch Hospital, ‘s-Hertogenbosch, Netherlands.
  • Eugenie F.A. Gemen Laboratory of Hematology and Clinical Chemistry, Jeroen Bosch Hospital, ‘s-Hertogenbosch, Netherlands.
  • Esther de Vries | e.d.vries@jbz.nl Department of Pediatrics, Jeroen Bosch Hospital, ‘s-Hertogenbosch, Netherlands.

Abstract

We report the detailed long-term reconstitution of B-lymphocyte subpopulations, immunoglobulins, and specific antibody production after two courses of rituximab in a young, previously healthy girl with steroid-dependent autoimmune hemolytic anemia. B-lymphocyte subpopulations were surprisingly normal directly after reconstitution. However, there was a slower reconstitution after the second rituximab course, especially of non-switched and switched memory B-lymphocytes, and a temporary decline in IgM below age-matched reference values.

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Author Biography

Esther de Vries, Department of Pediatrics, Jeroen Bosch Hospital, ‘s-Hertogenbosch

 


Published
2011-12-13
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Issue
Section
Brief Reports
Keywords:
Autoimmune hemolytic anemia, Rituximab, Child, Immune reconstitution, B-lymphocytes
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How to Cite
van der Linde, A. A., Schatorjé, E. J., van der Weij, A. M., Gemen, E. F., & de Vries, E. (2011). B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemia. Pediatric Reports, 3(4), e28. https://doi.org/10.4081/pr.2011.e28