Two cases of esophageal eosinophilia: eosinophilic esophagitis or gastro-esophageal reflux disease?

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Ozlem Yilmaz *
Hacer Ilbilge Ertoy Karagol
Erdem Topal
Aysel Unlusoy Aksu
Odul Egritas
Ipek Isık Gonul
Arzu Bakirtas
(*) Corresponding Author:
Ozlem Yilmaz | drozlemyilmaz09@gmail.com

Abstract

Eosinophilic esophagitis (EoE) and gastro-esophageal reflux disease are among the major causes of isolated esophageal eosinophilia. Isolated esophageal eosinophilia meeting criteria for EoE may respond to proton pump inhibitor (PPI) treatment. This entity is termed proton pumps inhibitor responsive esophageal eosinophilia (PPI-REE). Gastro-esophageal reflux is thought to comprise a subgroup of patients with PPI-REE. According to the latest guidelines, PPI responsiveness distinguishes people with PPI-REE from patients having EoE (non-responders). In this report, two unusual cases with findings belonging to both EoE and PPI-REE are discussed with known and unknown facts.

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