Necrotizing enterocolitis and focal intestinal perforation in neonatal intensive care units in the state of Baden-Württemberg, Germany

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Thomas Böhler *
Ingo Bruder
Peter Ruef
Jörg Arand
Manfred Teufel
Matthias Mohrmann
Roland Hentschel
(*) Corresponding Author:
Thomas Böhler | thomas.boehler@uni-heidelberg.de

Abstract

In preterm infants with very low birth weight (VLBW) <1500 g the most important acquired intestinal diseases are necrotising enterocolitis (NEC) and focal intestinal perforation (FIP). We analyzed data of the neonatology module of national external comparative quality assurance for inpatients in the state of Baden-Württemberg, Germany. Between 2010 and 2012, 59 of 3549 VLBW infants developed FIP (1.7%), 128 of them NEC (3.6%). In approximately 3% of infants with BW<1000 g FIP was diagnosed, which was nearly 9 times more often than in infants with BW between 1250 and 1499 g (FIP frequency 0.36%). NEC frequency increased with decreasing BW and was more than 10 times higher in the smallest infants (BW<750 g: 7.87%) compared to those with BW between 1250 and 1499 g (0.72%). The BW limit of 1250 g differentiates between groups of patients with distinguished risks for NEC and FIP.

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