Intraventricular ciprofloxacin usage in treatment of multidrug-resistant central nervous system infections: report of four cases

  • Ayse Karaaslan Department of Pediatric Infectious Diseases, Marmara University School of Medicine, Istanbul, Turkey.
  • Eda Kepenekli Kadayifçi Department of Pediatric Infectious Diseases, Marmara University School of Medicine, Istanbul, Turkey.
  • Ozden Turel Department of Pediatric Infectious Diseases, Marmara University School of Medicine, Istanbul, Turkey.
  • Demet Gedikbaşi Toprak Department of Pediatric Infectious Diseases, Marmara University School of Medicine, Istanbul, Turkey.
  • Ahmet Soysal | ahsoysal@yahoo.com Department of Pediatric Infectious Diseases, Marmara University School of Medicine, Istanbul, Turkey.
  • Mustafa Bakir Department of Pediatric Infectious Diseases, Marmara University School of Medicine, Istanbul, Turkey.

Abstract

In recent years, multidrug-resistant microorganisms appear as important nosocomial pathogens which treatment is quite difficult. As sufficient drug levels could not be achieved in cerebrospinal fluid during intravenous antibiotic therapy for central nervous system infections and due to multidrug-resistance treatment alternatives are limited. In this study, four cases of central nervous system infections due to multidrug-resistant microorganisms who were successfully treated with removal of the devices and intraventricular ciprofloxacin are presented. In conclusion, intraventricular ciprofloxacin can be used for treatment of central nervous system infections if the causative microorganism is sensitive to the drug and no other alternative therapy is available.

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Published
2014-12-12
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Section
Case Reports & Letters
Keywords:
intraventricular therapy, ciprofloxacin, children
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How to Cite
Karaaslan, A., Kepenekli Kadayifçi, E., Turel, O., Gedikbaşi Toprak, D., Soysal, A., & Bakir, M. (2014). Intraventricular ciprofloxacin usage in treatment of multidrug-resistant central nervous system infections: report of four cases. Pediatric Reports, 6(3). https://doi.org/10.4081/pr.2014.5619