Neonatal hemophilia: a rare presentation

  • Nuno Ferreira | nuno.ap.ferreira@gmail.com Neonatal Intensive Care Unit, Centro Hospitalar do Porto, Portugal.
  • Elisa Proença Neonatal Intensive Care Unit, Centro Hospitalar do Porto, Portugal.
  • Cristina Godinho Neonatal Intensive Care Unit, Centro Hospitalar do Porto, Portugal.
  • Dulce Oliveira Neonatal Intensive Care Unit, Centro Hospitalar do Porto, Portugal.
  • Ana Guedes Neonatal Intensive Care Unit, Centro Hospitalar do Porto, Portugal.
  • Sara Morais Clinical Hematology Department, Centro Hospitalar do Porto, Portugal.
  • Carmen Carvalho Neonatal Intensive Care Unit, Centro Hospitalar do Porto, Paraguay.

Abstract

Hemophilia A is a X-linked hereditary condition that lead to decreased factor VIII activity, occurs mainly in males. Decreased factor VIII activity leads to increased risk of bleeding events. During neonatal period, diagnosis is made after post-partum bleeding complication or unexpected bleeding after medical procedures. Subgaleal hemorrhage during neonatal period is a rare, severe extracranial bleeding with high mortality and usually related to traumatic labor or coagulation disorders. Subgaleal hemorrhage complications result from massive bleeding. We present a neonate with unremarkable family history and uneventful pregnancy with a vaginal delivery with no instrumentation, presenting with severe subgaleal bleeding at 52 hours of life. Aggressive support measures were implemented and bleeding managed. The unexpected bleeding lead to a coagulation study and the diagnosis of severe hemophilia A. There were no known sequelae. This case shows a rare hemophilia presentation reflecting the importance of coagulation studies when faced with unexplained severe bleeding.

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Published
2015-12-21
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Section
Case Reports & Letters
Keywords:
Hemophilia A, subgaleal hemorrhage, neonate, extracranial bleeding
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How to Cite
Ferreira, N., Proença, E., Godinho, C., Oliveira, D., Guedes, A., Morais, S., & Carvalho, C. (2015). Neonatal hemophilia: a rare presentation. Pediatric Reports, 7(4). https://doi.org/10.4081/pr.2015.6338