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Zika virus infection in a pediatric patient with acute gastrointestinal involvement

Svetoslav Slavov, Alessandra Matsuno, Aparecida Yamamoto, Katia Otaguiri, Maria Cervi, Dimas Covas, Simone Kashima
  • Svetoslav Slavov
    Blood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto; Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, Brazil | svetoslav.slavov@hemocentro.fmrp.usp.br
  • Alessandra Matsuno
    Department of Pediatrics, Faculty of Medicine of Ribeirão Preto, Brazil
  • Aparecida Yamamoto
    Department of Pediatrics, Faculty of Medicine of Ribeirão Preto, Brazil
  • Katia Otaguiri
    Blood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto; Department of Clinical, Toxicological and Bromatological Analyses, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil
  • Maria Cervi
    Department of Pediatrics, Faculty of Medicine of Ribeirão Preto, Brazil
  • Dimas Covas
    Blood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto; Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, Brazil
  • Simone Kashima
    Blood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto; Department of Clinical, Toxicological and Bromatological Analyses, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil

Abstract

Zika virus (ZIKV) is a mosquito-borne flavivirus, which has been related to severe neurological complications in neonates. However, many clinical aspects of the infection remain unclear, especially in pediatric patients. In this case report we describe the uncommon presentation of ZIKV infection in a pediatric patient with acute gastrointestinal involvement hospitalized in a Brazilian Emergency Unit. Dengue hemorrhagic fever was initially suspected, however, the molecular result for Dengue was negative. Molecular testing for other arboviruses (ZIKV and Chikungunya), revealed positive for ZIKV RNA result in both blood and saliva. The ZIKV load in saliva (6.947 copies/mL) was higher than the vetected ZIKV RNA in plasma (1.945 copies/mL). Additionally, the performed abdominal ultrasound revealed mesenteric lymphadenitis without abdominal retention of fluids. The presentation of this case demonstrates that ZIKV can be involved in a broader range of clinical conditions than currently assumed, including pediatric emergencies, especially in regions with extensive ZIKV outbreaks.

Keywords

Zika virus; ZIKV; Abdominal pain; Viral load

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Submitted: 2017-08-03 18:13:00
Published: 2018-01-03 10:51:27
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Copyright (c) 2017 Svetoslav Nanev Slavov, Alessandra Kimie Matsuno, Aparecida Yulie Yamamoto, Katia Kaori Otaguiri, Maria Célia Cervi, Dimas Tadeu Covas, Simone Kashima

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
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