Rheumatology Reports 2017-01-19T13:57:56+01:00 Emanuela Fusinato Open Journal Systems <p><strong>Rheumatology Reports</strong> is an international, open access, peer-reviewed journal publishing high quality papers about any rheumatological condition, musculoskeletal medicine and surgery. The journal welcomes papers on clinical, translational or basic research (in humans and in experimental model systems) that improve rheumatology clinical practice or enhance current understanding of rheumatic disease mechanisms. <strong>Rheumatology Reports</strong> aims to provide rapid publication of accepted papers and to give accurate scientific feed-back to all submissions by experts in the field.</p> A rare hereditary disease: Muckle-Wells syndrome 2017-01-19T13:57:56+01:00 Nitya Ramreddy Aviva Hopkins Carlos Lozada Cryopyrin associated periodic syndrome (CAPS) is a dominantly-inherited autoinflammatory disease, which is included in the group of periodic fever syndromes. It is caused by a defect in the regulation of inflammatory cytokines, particularly interleukin-1β. CAPS encompasses a spectrum of three phenotypes of increasing severity: familial cold autoinflammatory syndrome, Muckle-Wells syndrome (MWS) and neonatal onset multisystem inflammatory disease. We report the case of a 58-year-old male, who had migratory joint pains, daily urticaria, chills, and episodic conjunctivitis since childhood and hearing loss in his 20s with a family history of similar symptoms. He was diagnosed with MWS after being found to have a <em>R262W</em> gene mutation in <em>NLRP3</em> gene and successfully treated with canakinumab. After his discovery, other 1<sup>st</sup> and 2<sup>nd</sup> degree family members with similar complaints were found to have the same genetic mutation and were also successfully treated with canakinumab. 2016-08-18T11:55:55+02:00 ##submission.copyrightStatement## Pulsed radiofrequency therapy might be not inferior to thermal neurotomy in lumbar facet joint pain: a commentary 2017-01-19T13:57:54+01:00 Haiko Sprott Norina Bergamin Armin Aeschbach The effects of pulsed radiofrequency treatment in low back pain was evaluated in a routine clinical setting and compared with thermal neurotomy of nerve structures of the facet joint. The treatment of 19 patients with lumbar facet joint pain was prospectively evaluated. Follow-ups were recorded at 6 weeks and 6 months after intervention. Patients with ≥50% pain relief following controlled diagnostic local anesthetic block underwent medial branch neurotomy with thermal continuous radiofrequency (CRF, n=16) or pulsed radiofrequency (PRF, n=3). Experiences between the two radiofrequency modes in the treatment of facet joint pain were recorded. In the overall population, a facet joint pain reduction of 23% at 6 weeks, 20% at 6 months and an improvement in various clinical scores was achieved. CRF and PRF appeared to be similarly effective in the treatment of facet joint pain, providing pain relief for at least 6 months. These observations should encourage pain researcher to design meaningful studies to further address this concept. 2016-08-18T11:48:13+02:00 ##submission.copyrightStatement## Systemic lupus erythematosus and extreme thrombocytosis without autosplenectomy 2016-05-18T16:24:18+02:00 Austin Anderson Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterized by multiorgan system involvement. Hematologic manifestations are common in SLE and include thrombocytopenia in as many as 50% of patients. Thrombocytosis is much less common in SLE, occurring in less than 5% of patients, and is typically reported in association with autosplenectomy. The following case report describes a 35-year-old female patient who presented for evaluation with extreme thrombocytosis of unclear etiology. The patient was diagnosed with reactive thrombocytosis due to active SLE for which treatment with corticosteroids and plaquenil was provided with subsequent decline in platelet counts. This report highlights the importance of considering SLE in the differential for thrombocytosis despite its classic association with thrombocytopenia. 2015-12-30T11:09:17+01:00 ##submission.copyrightStatement## Successful treatment of neuro-Behçet’s disease with infliximab: four years follow-up 2016-05-18T16:24:17+02:00 Manjinder Kaur Emily S. Nia Rebecca A. Millius Dominick G. Sudano Jeffrey R. Lisse Neuro-Behçet’s disease (NBD) is a rare but severe manifestation of Behçet’s disease. Patients with NBD tend to have high morbidity and mortality. Some patients do not respond adequately to conventional therapy (corticosteroids and immunosuppressants). This has led to treatment gaps in the therapy of NBD. There are reports in the literature of patients with Behçet’s disease responding to anti-TNF therapy. We present a case of a male patient with biopsy proven cerebral vasculitis presenting as NBD who has been in remission with near resolution of cerebral magnetic resonance imaging lesions for 4 years following treatment with infliximab and azathioprine. 2015-10-20T09:43:14+02:00 ##submission.copyrightStatement##