Urine diacetylated spermine might be a nonspecific tumor marker in canine neoplasia

  • Mitsuhiro Isaka | isaka_m@hotmail.com Veterinary Medical Center, Japan.
  • Ito Noriko Marble Veterinary Medical Center, Japan.
  • Kuwahara Takeshi Marble Veterinary Medical Center, Japan.
  • Takahasi Yosuke Marble Veterinary Medical Center, Japan.
  • Onoue Midori Marble Veterinary Medical Center, Japan.
  • Arase Yurie Marble Veterinary Medical Center, Japan.
  • Namba Shinichi Marble Veterinary Medical Center, Japan.
  • Ryuichi Sekizawa Metaboscreen Co., Ltd, Japan.

Abstract

Diacetylated spermine, a polyamine, is clinically used as a tumor marker in human medicine. The purpose of this study was to evaluate the usefulness of diacetylated spermine as a nonspecific tumor marker in dogs. One hundred six dogs were randomly selected and divided into 4 groups (cancer-bearing, n=23; control, n=44; young, n=24; inflammatory, n=15). Urine samples were collected to measure diacetylated spermine and creatinine levels. The diacetylated spermine concentration was determined by enzyme-linked immunoassay, standardized by creatinine concentration. The urine diacetylated spermine concentration was markedly significant elevated in cancer-bearing dogs, as compared to that in control dogs (P=0.0081). Whilst the urine diacetylated spermine level in cancer-bearing group was not markedly different from that in the young group, there was significant different between levels in the control and young groups (P=0.019). No significant difference was observed between the inflammatory and cancer-bearing groups. It is suggested that urine diacetylated spermineis a useful tumor marker in dogs over 2 years of age.

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Published
2011-12-12
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Original Articles
Keywords:
diacetylated spermine, urine, tumor marker, canine
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How to Cite
Isaka, M., Noriko, I., Takeshi, K., Yosuke, T., Midori, O., Yurie, A., Shinichi, N., & Sekizawa, R. (2011). Urine diacetylated spermine might be a nonspecific tumor marker in canine neoplasia. Veterinary Science Development, 1(1), e16. https://doi.org/10.4081/vsd.2011.3771