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Urine diacetylated spermine might be a nonspecific tumor marker in canine neoplasia

Mitsuhiro Isaka, Ito Noriko, Kuwahara Takeshi, Takahasi Yosuke, Onoue Midori, Arase Yurie, Namba Shinichi, Ryuichi Sekizawa
  • Ito Noriko
    Marble Veterinary Medical Center, Japan
  • Kuwahara Takeshi
    Marble Veterinary Medical Center, Japan
  • Takahasi Yosuke
    Marble Veterinary Medical Center, Japan
  • Onoue Midori
    Marble Veterinary Medical Center, Japan
  • Arase Yurie
    Marble Veterinary Medical Center, Japan
  • Namba Shinichi
    Marble Veterinary Medical Center, Japan
  • Ryuichi Sekizawa
    Metaboscreen Co., Ltd, Japan

Abstract

Diacetylated spermine, a polyamine, is clinically used as a tumor marker in human medicine. The purpose of this study was to evaluate the usefulness of diacetylated spermine as a nonspecific tumor marker in dogs. One hundred six dogs were randomly selected and divided into 4 groups (cancer-bearing, n=23; control, n=44; young, n=24; inflammatory, n=15). Urine samples were collected to measure diacetylated spermine and creatinine levels. The diacetylated spermine concentration was determined by enzyme-linked immunoassay, standardized by creatinine concentration. The urine diacetylated spermine concentration was markedly significant elevated in cancer-bearing dogs, as compared to that in control dogs (P=0.0081). Whilst the urine diacetylated spermine level in cancer-bearing group was not markedly different from that in the young group, there was significant different between levels in the control and young groups (P=0.019). No significant difference was observed between the inflammatory and cancer-bearing groups. It is suggested that urine diacetylated spermineis a useful tumor marker in dogs over 2 years of age.

Keywords

diacetylated spermine, urine, tumor marker, canine

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Submitted: 2011-10-10 08:49:07
Published: 2011-12-12 15:39:53
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Copyright (c) 2011 Mitsuhiro Isaka, Ito Noriko, Kuwahara Takeshi, Takahasi Yosuke, Onoue Midori, Arase Yurie, Namba Shinichi, Ryuichi Sekizawa

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