PANDAS Syndrome: diagnosis, physiopathology, etiology and treatments


Submitted: 27 November 2023
Accepted: 8 July 2024
Published: 7 November 2024
Abstract Views: 814
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Authors

The aim of this paper is to carry out a narrative review of the main contributions in the literature relating to PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections) Syndrome. The literature search was carried out using Pubmed, Psycinfo, and PsycArticles databases.

The diagnostic criteria and etiology are still debated and objects of research. Several studies suggest that streptococcal infections induce an immunological response that causes basal ganglia modifications. Currently, treatments in practice are pharmacological, immunological, surgical, and psychological, used in combination for greater efficacy. Given the complexity of the syndrome, further studies are needed to better define the syndrome and lead towards targeted treatments.


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