MicroRNAs as biomarkers  for the diagnosis and prognosis of human cancer

Daniela Asslaber; Josefina Piñón  Hofbauer; Richard Greil; Alexander Egle

doi:10.4081/jnai.2010.2130

MicroRNAs as biomarkers for the diagnosis and prognosis of human cancer

https://doi.org/10.4081/jnai.2010.2130

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Vol. 1 No. 1 (2010)

Submitted: 23 October 2010
Accepted: 1 December 2010

Published: 13 December 2010

Micro RNA, Cancer, Biomarker, Chronic Lymphocytic Leukemia

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Authors

Daniela Asslaber
a.egle@salk.at
Laboratory for Immunological and Molecular Cancer Research, University Hospital, Salzburg, Austria.
Josefina Piñón Hofbauer
Richard Greil
Alexander Egle

miRNAs are small-noncoding RNA molecules that regulate gene expression on a posttranscriptional level. A number of oncogenes and tumor suppressors were found to be targets of miRNAs and global miRNA expression signatures were able to distinguish between cancerous and non-cancerous tissues. Therefore it was not surprising that some miRNAs could be linked to the pathogenesis of cancer. In this review we provide an overview of the use of microRNAs as diagnostic and prognostic tools in cancer and focus on the use of miRNA expression as biomarker for disease activity.

Daniela Asslaber, Laboratory for Immunological and Molecular Cancer Research, University Hospital, Salzburg

not applicable

Supporting Agencies

This work was supported by Austrian FWF grants P19481 and L488 to A.E., Austrian National Bank grant 10990 to A.E., and by the state of Salzburg and the SFB 021 to R.G.

Asslaber, D., Piñón Hofbauer, J., Greil, R., & Egle, A. (2010). MicroRNAs as biomarkers for the diagnosis and prognosis of human cancer. Journal of Nucleic Acids Investigation, 1(1), e14. https://doi.org/10.4081/jnai.2010.2130