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Angiomatoid fibrous histiocytoma in a 25-year-old male

Aaron Scott Mansfield, Brenda Larson, Scott L. Stafford, Thomas C. Shives, Michael G. Haddock, David Dingli
  • Brenda Larson
    Park Nicollet Frauenshuh Cancer Center, St. Louis Park, MN,
  • Scott L. Stafford
    Mayo Clinic Department of Radiation Oncology,
  • Thomas C. Shives
    Mayo Clinic Rochester, MN Department of Orthopedic Oncology,
  • Michael G. Haddock
    Mayo Clinic Rochester, MN Department of Radiation Oncology,
  • David Dingli
    Mayo Clinic Rochester, MN Department of Hematology,


Angiomatoid fibrous histiocytoma (AFH) is a rare disease that is often misdiagnosed initially. Patients can present with a clinical picture concerning for other diseases, and pathologic review is not always revealing. Molecular diagnostics are increasingly being utilized to detect gene fusions characteristic for AFH. Surgery remains the mainstay of management, and can effectively control local recurrences and metastases. Herein we describe a case report of a 25-year-old gentleman whose presentation was concerning for lymphoma. Subsequently we review of the relevant literature.


Angiomatoid fibrous histiocytoma, soft tissue tumor

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Submitted: 2010-01-05 21:16:33
Published: 2010-03-24 16:03:52
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