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Clear-cell variant urothelial carcinoma of the bladder: a case report and review of the literature

Mario W. Kramer, Mahmoud Abbas, Stefanie Pertschy, Jan Ulrich Becker, Hans-Heinrich Kreipe, Markus A. Kuczyk, Axel S. Merseburger, Hossein Tezval
  • Mario W. Kramer
    Department of Urology and Urologic Oncology, Hanover Medical School, Hanover, Germany
  • Mahmoud Abbas
    Institute of Pathology, Hanover Medical School, Hanover, Germany
  • Stefanie Pertschy
    Department of Radiology, Hanover Medical School, Hanover, Germany
  • Jan Ulrich Becker
    Institute of Pathology, Hanover Medical School, Hanover, Germany
  • Hans-Heinrich Kreipe
    Institute of Pathology, Hanover Medical School, Hanover, Germany
  • Markus A. Kuczyk
    Department of Urology and Urologic Oncology, Hanover Medical School, Hanover, Germany
  • Axel S. Merseburger
    Department of Urology and Urologic Oncology, Hanover Medical School, Hanover, Germany

Abstract

Clear cell variants of transitional cell carcinomas (TCC) of the bladder are extremely rare tumors. Only 6 cases have been reported until now. We report of a 67 year old man who presented with fast growing tumor disease. While initial diagnosis showed localized bladder tumor, final histopathology revealed pT4, G3, L1 urothelial carcinoma with clear cell differentiation. No more than 14 weeks after initial diagnosis the patient died from multi-organ failure after unsuccessful salvage laparotomy which showed massive tumor burden within the pelvis and peritoneal carcinosis. This case demonstrated an extremely fast tumor growth. Therefore, patients with clear cell urothelial carcinoma should be treated vigorously and without time delay. We present a case of clear cell variant of TCC which exhibited an extremely aggressive behavior. To our knowledge this is the fifth report of this rare disease.

Keywords

clear-cell, TCC, urothelial carcinoma, adenocarcinoma

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Submitted: 2012-06-03 13:40:28
Published: 2012-10-10 17:33:20
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Copyright (c) 2012 Mario W. Kramer, Mahmoud Abbas, Stefanie Pertschy, Jan Ulrich Becker, Hans-Heinrich Kreipe, Markus A. Kuczyk, Axel S. Merseburger, Hossein Tezval

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