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Giant cell angioblastoma in an adult: a unique presentation

Susanna Crivelli-Ochsner, Beata Bode-Lesniewska, Yvonne Nussbaumer-Ochsner, Bruno Fuchs
  • Susanna Crivelli-Ochsner
    Department of Medical Oncology, Cantonal Hospital of Winterthur, Winterthur, Switzerland |
  • Beata Bode-Lesniewska
    University Hospital of Zurich, Institute of Surgical Pathology, Zurich, Switzerland
  • Yvonne Nussbaumer-Ochsner
    Department of Internal Medicine, Cantonal Hospital of Muensterlingen, Muensterlingen, Switzerland
  • Bruno Fuchs
    Department of Orthopedic Oncology, Balgrist University Hospital, Zurich, Switzerland


Giant cell angioblastoma is a very rare, locally destructive vascular tumor of intermediate malignancy without metastatic potential. There are only a few cases reported in the literature exclusively in the soft tissue of children. For the first time, we report on an adult patient with a giant cell angioblastoma in the popliteal fossa. The therapy included tumor resection with favorable clinical, oncological and functional outcome. Due to its locally destructive nature, surgery remains the mainstay of treatment. Histologically, giant cell angioblastoma is comprised of nodular aggre- gates of histiocytoid cells arranged around bland angiomatous spaces. Because of insufficient available data in regard to the definition of the entity, diagnostic criteria and its biological potential, it is not included in the new World Health Organization classification of tumors of soft tissue and bone. The differential diagnosis includes plexiform fibrohistiocytic tumor, myofibroma and giant cell fibroblastoma.


giant cell, angioblastoma, vascular tumor, soft-tissue tumor, intermediate malignancy

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Submitted: 2013-02-03 21:48:17
Published: 2013-07-01 14:30:40
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Copyright (c) 2013 Susanna Crivelli-Ochsner, Beata Bode-Lesniewska, Yvonne Nussbaumer-Ochsner, Bruno Fuchs

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