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Mucinous cystadenocarcinoma of the breast: the challenge of diagnosing a rare entity

Nektarios Koufopoulos, Christina Goudeli, John Syrios, Evangelos Filopoulos, Lubna Khaldi
  • Christina Goudeli
    Department of Gynecology, Saint Savvas Anti-Cancer Hospital, Athens, Greece
  • John Syrios
    Department of Oncology, Saint Savvas Anti-Cancer Hospital, Athens, Greece
  • Evangelos Filopoulos
    Breast Surgical Clinic, Saint Savvas Anti-Cancer Hospital, Athens, Greece
  • Lubna Khaldi
    Department of Pathology, Saint Savvas Anti-Cancer Hospital, Athens, Greece

Abstract

Mucinous cystadenocarcinoma is an extremely rare variant of primary breast tumor which is histologically similar to mucinous cystadenocarcinoma of the ovary and pancreas. Herein we report a case of a 63 years old woman diagnosed with diverse histological types of non-synchronous rare primary breast tumors, a medullary carcinoma of the right breast and a mucinous cystadenocarcinoma of the left breast. Macroscopically the neoplasm appeared multilocular filled with mucoid material. Under light microscopy the cystic areas were lined by columnar cells with abundant intracellular and extracellular mucin. Solid areas were composed of tall columnar cells with intracellular mucin. Moderate to marked atypia was noticed and tumor cells stained positive for cytokeratin 7 and negative for cytokeratin 20. Moreover tumor cells displayed a basal like immunophenotype expressed as followed: ER negative, PR negative, HER-2 negative, cytokeratin (CK5/6) positive and EGFR positive.

Keywords

Basal like, Breast, Embryogenesis, Mucinous cystadenocarcinoma

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Submitted: 2016-12-27 19:22:59
Published: 2017-10-03 14:18:32
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Copyright (c) 2017 Nektarios Koufopoulos, Christina Goudeli, John Syrios, Evangelos Filopoulos, Lubna Khaldi

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