Pathogenetic mechanisms in B-cell lymphomagenesis


https://doi.org/10.4081/hmr.v1i5.243
Vol. 1 No. 5: International Symposium on Infection-Driven Lymphomas, Rome, April 17-19, 2005
Published: May 29, 2009
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The pathogenesis of B-cell non Hodgkin lymphoma (NHL) is a highly complex process involving genetic alterations in the tumor clone as well as biologic alterations in the host. Three main mechanisms of lymphomagenesis are recognized: i) accumulation of gene alterations in the tumor genome; ii) infection of the tumor clone by an oncogenic virus; iii) stimulation and selection of tumor cells by an antigen. As in most human cancers, the genetic lesions involved in B-cell NHL include the activation of proto-oncogenes and the disruption of tumor suppressor genes. In contrast to solid tumors, the pathogenesis of B-cell NHL involves one or few genetic lesions generally represented by chromosomal translocation.

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Rossi, D., Capello, D., & Gaidano, G. (2009). Pathogenetic mechanisms in B-cell lymphomagenesis. Hematology Meeting Reports (formerly Haematologica Reports), 1(5). https://doi.org/10.4081/hmr.v1i5.243
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