Molecular pathology of post-transplant lymphoproliferative disorders


https://doi.org/10.4081/hmr.v1i5.249
Vol. 1 No. 5: International Symposium on Infection-Driven Lymphomas, Rome, April 17-19, 2005
Published: May 29, 2009
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Posttransplant lymphoproliferative disorders (PTLD) are a major complication of solid organ transplantation and are due to the chronic administration of iatrogenic immunosuppression.1,2 Most PTLD are of B cell origin, frequently involve extra-nodal sites, and display a marked clinical aggressiveness. Despite these common features, PTLD display histological and molecular heterogeneity and may present at different times after transplantation.1-5 Early onset (<1 year after transplantation) PTLD are mainly regarded as Epstein Barr virus (EBV)-driven lymphoproliferations that are frequently, though not always, polyclonal or oligoclonal.1-5 Conversely, most late onset (> 1 year after transplantation) PTLD are true monoclonal lymphoid malignancies that harbor EBV infection only in a fraction of cases.1-5

Supporting Agencies


Capello, D., Cerri, M., Rossi, D., Berra, E., Deambrogi, C., Franceschetti, S., Vendramin, C., De Paoli, L., Primon, V., Rus, C., Destro, T., Conconi, A., & Gaidano, G. (2009). Molecular pathology of post-transplant lymphoproliferative disorders. Hematology Meeting Reports (formerly Haematologica Reports), 1(5). https://doi.org/10.4081/hmr.v1i5.249
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