Bortezomib therapy for refractory/relapsed multiple myeloma


Published: June 3, 2009
Abstract Views: 150
PDF: 150
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

The proteasome is a multienzyme complex found in all eukaryotic cells that functions to degrade most short-lived and long-lived intracellular proteins after their conjugation to ubiquitin. Many of these proteins are involved in cell cycle regulation, and their timely degradation after polyubiquitination is essential for normal cell cycling, function and survival. Inhibition of proteasome activity results in accumulation of these proteins within the cells, with subsequent cell-cycle arrest, apoptosis and downregulation of angiogenesis.

Supporting Agencies


Cavo, M. (2009). Bortezomib therapy for refractory/relapsed multiple myeloma. Hematology Meeting Reports (formerly Haematologica Reports), 1(8). https://doi.org/10.4081/hmr.v1i8.288

Downloads

Citations