Thalidomide analogs


https://doi.org/10.4081/hmr.v1i8.292
Vol. 1 No. 8: New Drugs in Hematology, Bologna, October 9-11, 2005
Published: June 3, 2009
Abstract Views: 172
PDF: 486
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Thalidomide-based regimens have shown remarkable activity in relapsed-refractory multiple myeloma (MM) so that their use has been successfully extended to newly diagnosed patients. Thalidomide-dexamethasone combination has demonstrated to be superior to VAD in terms of both response rate and relative reduction of serum or urine M component,1 and these results are being confirmed in multicenter randomised ongoing trials.2 A major drawback of thalidomide is represented by its side effects; more than half of the patients complain about lethargy and constipation, deep venous thromboses occur in up to 15-20% of newly diagnosed patients treated with thalidomide-dexamethasone unless a proper prophylaxis is performed3-4 grade ≥2 WHO peripheral neuropathy is reported in 60% of the patients treated longer than 1 year;5 the incidence and extent of side effects limit the usage of thalidomide in other hematological conditions such as Waldenstrom macroglobulinemia, AL amyloidosis and, above all, myelofiblosis.1

Supporting Agencies


Tosi, P., Zamagni, E., Cangini, D., Tacchetti, P., Perrone, G., Ceccolini, M., & Cavo, M. (2009). Thalidomide analogs. Hematology Meeting Reports (formerly Haematologica Reports), 1(8). https://doi.org/10.4081/hmr.v1i8.292
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