Tissue factor pathway inhibitor and cancer


https://doi.org/10.4081/hmr.v1i9.313
Vol. 1 No. 9: 3rd International Conference on Thrombosis and Hemostasis Issues in Cancer, Bergamo, October 14-16, 2005
Published: June 3, 2009
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The coagulation protease cascade and the fibrinolytic system are leading to the synthesis of two serine-proteases that are essential for normal hemostasis but these enzymes also play important regulatory roles in angiogenesis, cancer cell migration and tumor growth. Tissue factor (TF) is the physiological trigger of coagulation cascade and is mainly regulated by TFPI-1 (tissue factor pathway inhibitor), a kunitz-domain serine protease inhibitor. But, another protein analogous to TFPI-1 and named TFPI-2 is also present in large amounts in extracellular matrices (ECM), and has been identified as playing an important role in cancer invasion.

Supporting Agencies


Gruel, Y., Rollin, J., Regina, S., Iochmann, S., Hube, F., & Reverdiau, P. (2009). Tissue factor pathway inhibitor and cancer. Hematology Meeting Reports (formerly Haematologica Reports), 1(9). https://doi.org/10.4081/hmr.v1i9.313
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