Tissue factor-PAR2 signaling crosstalk in cancer and angiogenesis


https://doi.org/10.4081/hmr.v1i9.314
Vol. 1 No. 9: 3rd International Conference on Thrombosis and Hemostasis Issues in Cancer, Bergamo, October 14-16, 2005
Published: June 3, 2009
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PDF: 412
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Tissue factor (TF) has now well recognized roles as a signaling receptor involved in the regulation of angiogenesis, tumor growth, metastasis and inflammation. TF initiates coagulation, leading to thrombin signaling through G protein coupled, protease activated receptors (PAR) 1, 3, and 4.1 However, the signaling activities of the TF-VIIa binary and the TF-VIIa-Xa ternary complex may occur prior to or even independently of generalized coagulation activation that lead to fibrin generation, platelet activation and thrombus formation.2 The TF-VIIa complex activates PAR2 and the product of initiation of coagulation, Xa, while still assembled in the transient ternary TF-VIIa-Xa complex, signals through PAR1 or PAR2.

Supporting Agencies


Ruf, W. (2009). Tissue factor-PAR2 signaling crosstalk in cancer and angiogenesis. Hematology Meeting Reports (formerly Haematologica Reports), 1(9). https://doi.org/10.4081/hmr.v1i9.314
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