Cytokine GRO-a is pivotal in thrombin-induced angiogenesis


https://doi.org/10.4081/hmr.v1i9.318
Vol. 1 No. 9: 3rd International Conference on Thrombosis and Hemostasis Issues in Cancer, Bergamo, October 14-16, 2005
Published: June 3, 2009
Abstract Views: 150
PDF: 316
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The pro-malignant role of thrombin in tumor adhesion, growth, metastasis and angiogenesis is well recognized.1-6 However, the mechanism of thrombin-induced angiogenesis is not clear. Vascular regulatory proteins and growth factors, particularly metalloproteinases (MMP-1, MMP-2, MMP-9), vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1), and angiopoietin-2 (Ang-2), are required for the regulation of blood vessel formation. Thrombin-induced angiogenesis in a chick chorioallantoic membrane (CAM) assay is associated with upregulation of the major vascular endothelial growth factor (VEGF) as well as Angiopoietin-2 (Ang-2).6 Thrombin also upregulates VEGF and the major VEGF receptor KDR in endothelial cells and induces the secretion of VEGF and Ang-1 from platelets. Thrombin upregulates Ang-2, MMP-1 and MMP-2 in endothelial cells. However, the cellular mechanisms responsible for thrombin-induced upregulation of these genes have not been established.

Supporting Agencies


Karpatkin, S. (2009). Cytokine GRO-a is pivotal in thrombin-induced angiogenesis. Hematology Meeting Reports (formerly Haematologica Reports), 1(9). https://doi.org/10.4081/hmr.v1i9.318
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