Lymphangiogenesis: a new paradigm for cancer progression and therapy


https://doi.org/10.4081/hmr.v1i9.326
Vol. 1 No. 9: 3rd International Conference on Thrombosis and Hemostasis Issues in Cancer, Bergamo, October 14-16, 2005
Published: June 3, 2009
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Angiogenesis and permeability of blood vessels are regulated by vascular endothelial growth factor (VEGF) via its two receptors VEGFR-1 and VEGFR-2. The VEGFR-3 receptor does not bind VEGF and its expression becomes restricted mainly to lymphatic endothelia during development. We have found that homozygous VEGFR-3 targeted mice die around midgestation due to failure of cardiovascular development. We have also purified and cloned the VEGFR-3 ligand, VEGF-C. Transgenic mice expressing VEGF-C show evidence of lymphangiogenesis and VEGF-C knockout mice have defective lymphatic vessels. The proteolytically processed form of VEGF-C binds also to VEGFR-2 and is angiogenic.

Supporting Agencies


Alitalo, K. (2009). Lymphangiogenesis: a new paradigm for cancer progression and therapy. Hematology Meeting Reports (formerly Haematologica Reports), 1(9). https://doi.org/10.4081/hmr.v1i9.326
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