Human memory Vγ9Vδ2 T cells require homeostatic cytokines for proliferation and differentiation


https://doi.org/10.4081/hmr.v2i3.358
Vol. 2 No. 3: Cervo Preclinical Working Conference, Cervo Ligure, October 6-8, 2005
Published: June 8, 2009
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We have analysed four subsets of human γg9Vδ2 T cells for their capacity to proliferate and differentiate in response to antigen or homeostatic cytokines. Antigen-stimulated cells acquired a central memory (TCM) or effector memory (TEM) phenotype, while IL-15-stimulated cells maintained their phenotype, with the exception of TCM cells, which expressed CD27 and CD45RA in various combinations. These results show that huma nVγ9Vδ2 memory T cells have different proliferation and differentiation potentials and that terminally differentiated (TEMRA) cells result from the TCM subset upon homeostatic proliferation in the absence of antigen.

Supporting Agencies


Caccamo, N., Meraviglia, S., Ferlazzo, V., Dieli, F., Guggino, G., La Mendola, C., & Salerno, A. (2009). Human memory Vγ9Vδ2 T cells require homeostatic cytokines for proliferation and differentiation. Hematology Meeting Reports (formerly Haematologica Reports), 2(3). https://doi.org/10.4081/hmr.v2i3.358
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