Update on galiximab: anti-CD80 monoclonal antibody


https://doi.org/10.4081/hmr.v2i5.734
Vol. 2 No. 5: New Drugs in Hematology, Bologna, Italy 5-7 October 2008
Published: June 23, 2009
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PDF: 230
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CD80 (B7.1) is a membranebound co-stimulatory molecule known for its role in regulating Tcell activity. Several studies suggest that it is also involved in the regulation of normal and malignant B-cells. CD80 is transiently expressed on the surface of activated B-cells, antigen-presenting cells, and T-cells, but is constitutively expressed on a variety of NHL’s (e.g. follicular lymphoma (FL), Hodgkin’s lymphoma, etc.). Galiximab is a chimeric (“primatized” = human IgG1 constant regions plus primate variable regions) anti-CD80 monoclonal antibody (mAb) with low immunogenicity. Cross-linking CD80 with anti-CD80 on lymphoma cells in vitro has been shown to induce antibodydependent cellular cytotoxicity (ADCC), upregulate proapoptotic molecules, and inhibit cell proliferation. 1 Another possible mechanism of action may involve immunomodulatory effects on host effector cells affecting the tumor microenvironment. In vivo, galiximab delays tumor growth and prolongs survival in a human lymphoma SCID mouse model.2

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Czuczman, M. (2009). Update on galiximab: anti-CD80 monoclonal antibody. Hematology Meeting Reports (formerly Haematologica Reports), 2(5). https://doi.org/10.4081/hmr.v2i5.734
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