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Anti-inflammatory activity of Syzygium cumini leaf against experimentally induced acute and chronic inflammations in rodents

Anirban Roy, Sanjib Bhattacharya, Jitendra N. Pandey, Moulisha Biswas
  • Sanjib Bhattacharya
    Affiliation not present
  • Jitendra N. Pandey
    Affiliation not present
  • Moulisha Biswas
    Affiliation not present

Abstract

Syzygium cumini (L.) Skeels (Myrtaceae), commonly known as Jam in Bengali, Jamun in Hindi and Black Plum or Black Berry in English, is a large size evergreen tree indigenous to India and is cultivated for its fruits. In the present study, the methanol extract of leaves from S. cumini (MESC) was evaluated for anti-inflammatory activity in experimental acute (carrageenan, histamine and serotonin induced rat paw oedema) and chronic models (cotton pellet induced rat granuloma). In all models, the MESC (100 and 200 mg/kg body wt. p.o.) exhibited significant anti-inflammatory activity (p < 0.001) in a dose dependent manner. These findings revealed that the S. cumini leaf had remarkable acute and chronic anti-inflammatory actions in the tested rodent models.

Keywords

Anti-inflammatory; chronic; mediators; Syzygium cumini; leaf.

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Submitted: 2011-05-26 13:41:35
Published: 2011-07-15 09:44:38
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Copyright (c) 2011 Anirban Roy, Sanjib Bhattacharya, Jitendra N. Pandey, Moulisha Biswas

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