Evaluation of central nervous system depressant activity of Cleome rutidosperma


https://doi.org/10.4081/ams.2012.e8
Vol. 2 No. 1 (2012)
Submitted: 28 September 2011
Accepted: 15 February 2012
Published: 22 May 2012
Cleome rutidosperma, CNS, anticonvulsant, potentiation, muscle relaxant, anti-anxiety
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The central nervous system (CNS) depressant activity of the ethanol extract (200 and 400 mg/kg) and its fractions (200 mg/kg each) of the aerial parts of Cleome rutidosperma was investigated in various models. The tested extract and its fractions showed significant (P<0.01) anxiolytic, anticonvulsant activity (in treating petit mal epilepsy) without any unwanted sedation effect. These findings justify the traditional use of this plant in CNS disorders.

Supporting Agencies


Bose, A., Khuntia, A., Gupta, J. K., & Si, S. (2012). Evaluation of central nervous system depressant activity of Cleome rutidosperma. Alternative Medicine Studies, 2(1), e8. https://doi.org/10.4081/ams.2012.e8

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