Evaluation of central nervous system depressant activity of Cleome rutidosperma

  • Anindya Bose | anindyabose_in@yahoo.com Dr. BC Roy College of Pharmacy and Allied Health Sciences, Durgapur, India.
  • Anuradha Khuntia Institute of Pharmacy and Technology, Salipur, Cuttack, Orissa, India.
  • Jayanta Kumar Gupta Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
  • Sudam Si School of Pharmaceutical Sciences, Institute for Technical Education and Research, Bhubaneswar, India.

Abstract

The central nervous system (CNS) depressant activity of the ethanol extract (200 and 400 mg/kg) and its fractions (200 mg/kg each) of the aerial parts of Cleome rutidosperma was investigated in various models. The tested extract and its fractions showed significant (P<0.01) anxiolytic, anticonvulsant activity (in treating petit mal epilepsy) without any unwanted sedation effect. These findings justify the traditional use of this plant in CNS disorders.

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Published
2012-05-22
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Original Articles
Keywords:
Cleome rutidosperma, CNS, anticonvulsant, potentiation, muscle relaxant, anti-anxiety
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How to Cite
Bose, A., Khuntia, A., Gupta, J. K., & Si, S. (2012). Evaluation of central nervous system depressant activity of Cleome rutidosperma. Alternative Medicine Studies, 2(1), e8. https://doi.org/10.4081/ams.2012.e8