The role of thalidomide as maintenance after autologous stem-cell transplantation in multiple myeloma


https://doi.org/10.4081/hmr.v3i3.559
Vol. 3 No. 3: 7th Meeting New Insights in Hematology Venice, Italy, 26-29 April 2009
Published: June 12, 2009
Abstract Views: 160
PDF: 170
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Major progress was obtained in the last ten years for treatment of multiple myeloma (MM). High dose chemotherapy with autologous stem – cell transplant (ASCT) and new drugs as thalidomide, lenalidomide and bortezomibe have completely changed the scenario of MM treatment. ASCT becomes the mainstay of MM treatment for patients up to 65 years old. This strategy has been tested in randomized clinical trials and it proven that ASCT can improve overall survival of MM patients. Unfortunately, the large majority of these patients will relapse in few years after ASCT. Strategies of maintenance were developed trying to improve the ASCT results. Thalidomide has been tested in this setting on at least 4 randomized clinical trials with a significant impact on response rate, event free and overall survival.

Supporting Agencies


Maiolino, A., Tietsche de Moraes Hungria, V., Nucci, M., & De Souza, C. (2009). The role of thalidomide as maintenance after autologous stem-cell transplantation in multiple myeloma. Hematology Meeting Reports (formerly Haematologica Reports), 3(3). https://doi.org/10.4081/hmr.v3i3.559
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