MicroRNAs in mouse models of lymphoid malignancies

  • Nicola A. O. Zanesi | nicola.zanesi@osumc.edu Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, United States.
  • Yuri Pekarsky Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, United States.
  • Francesco Trapasso Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, United States.
  • George Calin Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, United States.
  • Carlo M. Croce Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, United States.

Abstract

The discovery of microRNAs (miRNAs) has revealed a new layer of gene expression regulation that affects many normal and pathologic biological systems. Among the malignancies affected by the dysregulation of miRNAs there are cancers of lymphoid origin, in which miRNAs are thought to have tumor suppressive or tumor promoting activities, depending on the nature of their specific targets. In the last 4-5 years, the experimental field that provided the deepest insights into the in vivo biology of miRNAs is that of mouse modeling in which transgenic and knockout animals mimic, respectively, over-expression or down-regulation of specific miRNAs involved in human leukemia/lymphoma. This review discusses recent advances in our understanding of lymphoid malignancies based on the natural and engineered mouse models of three different miRNAs, miR-15a/16-1 cluster, miR-155, and miR-17-92 cluster.

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Published
2010-05-25
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Issue
Section
Reviews
Keywords:
Leukemia, microRNAs, Mouse models,
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How to Cite
Zanesi, N., Pekarsky, Y., Trapasso, F., Calin, G., & Croce, C. (2010). MicroRNAs in mouse models of lymphoid malignancies. Journal of Nucleic Acids Investigation, 1(1), e8. https://doi.org/10.4081/jnai.2010.1727