A 5-year old male with “leukemic form” of disseminated post-transplant lymphoproliferative disorder

  • Saadiya Haque | saadiyahaque@yahoo.com Department of Pathology Georgetown University Hospital, United States.
  • Bhaskar Kallakury Department of Pathology Georgetown University Hospital, United States.
  • Aziza Shad Department of Pediatric Oncology Georgetown University Hospital, Washington DC, USA., United States.
  • Kristen Snyder Department of Pediatric Oncology Georgetown University Hospital, Washington DC, USA., United States.

Abstract

Post-transplant lymphoproliferative disorder (PTLD) represents an abnormal lymphoid proliferation that occurs in recipients of solid organ or bone marrow allograft. It includes a diverse group of diseases ranging from polymorphic B-cell hyperplasia to frank malignant lymphoma. Clinical presentation is variable, ranging from asymptomatic to generalized lymphadenopathy, mononucleosis-like syndrome, nodal or extranodal tumors (usually gastrointestinal tract), systemic lymphomatous involvement, and rare (less than 1% of cases) fulminant disseminated disease. PTLD is more common in children than in adults. Younger patients usually present with mononucleosis-like symptoms. We present an unusual case of a 5-year old male who developed a widely disseminated leukemic form of PTLD, involving lymph nodes, tonsils, multiple organs, bone marrow, cerebrospinal fluid, and peripheral blood.

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Author Biography

Saadiya Haque, Department of Pathology Georgetown University Hospital
4th year pathology resident
Published
2010-03-11
Info
Issue
Section
Case Reports & Letters
Keywords:
posttransplant, lymphoproliferative, ebv, immunosuppression
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How to Cite
Haque, S., Kallakury, B., Shad, A., & Snyder, K. (2010). A 5-year old male with “leukemic form” of disseminated post-transplant lymphoproliferative disorder. Pediatric Reports, 2(1), e6. https://doi.org/10.4081/pr.2010.e6