A 5-year old male with “leukemic form” of disseminated post-transplant lymphoproliferative disorder

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Saadiya Haque *
Bhaskar Kallakury
Aziza Shad
Kristen Snyder
(*) Corresponding Author:
Saadiya Haque | saadiyahaque@yahoo.com

Abstract

Post-transplant lymphoproliferative disorder (PTLD) represents an abnormal lymphoid proliferation that occurs in recipients of solid organ or bone marrow allograft. It includes a diverse group of diseases ranging from polymorphic B-cell hyperplasia to frank malignant lymphoma. Clinical presentation is variable, ranging from asymptomatic to generalized lymphadenopathy, mononucleosis-like syndrome, nodal or extranodal tumors (usually gastrointestinal tract), systemic lymphomatous involvement, and rare (less than 1% of cases) fulminant disseminated disease. PTLD is more common in children than in adults. Younger patients usually present with mononucleosis-like symptoms. We present an unusual case of a 5-year old male who developed a widely disseminated leukemic form of PTLD, involving lymph nodes, tonsils, multiple organs, bone marrow, cerebrospinal fluid, and peripheral blood.

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Author Biography

Saadiya Haque, Department of Pathology Georgetown University Hospital

4th year pathology resident