Combination antifungal therapy and surgery for the treatment of invasive pulmonary aspergillosis after hematopoietic stem cell transplantation

Main Article Content

Simone Cesaro
Marta Pillon *
Elisabetta Calore
Rita Alaggio
Piergiorgio Gamba
Silvia Bergamo
Chiara Mainardi
Tiziana Toffolutti
Anna Pegoraro
Chiara Messina
(*) Corresponding Author:
Marta Pillon |


An 8-year old boy, affected by severe aplastic anemia, developed a probable pulmonary invasive aspergillosis (IA) early after a second unrelated allogeneic hematopoietic stem cell transplant (HSCT). He was treated promptly with the combination of liposomal amphotericin B and caspofungin. Despite the initial stabilization, the patient deteriorated and the antifungal therapy was switched to voriconazole and caspofungin. The patient gradually improved and was discharged home on day +29 post-HSCT on oral voriconazole. On day +119, a sudden episode of hemoptysis occurred and a right superior lobectomy was decided to remove the residual aspergilloma. The patient is now alive and well more than 24 months from HSCT. This case demonstrated that antifungal combination therapy and surgery are valid options to cure pulmonary IA even in patients at high-risk and severely immunosuppressed.

Downloads month by month


Download data is not yet available.

Article Details

Most read articles by the same author(s)