The impact of high-fat diet-induced oxidative stress on micro RNA’s in various tissues


Submitted: 20 May 2022
Accepted: 25 August 2022
Published: 2 July 2023
Abstract Views: 1798
PDF: 163
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

  • Manikanta Vinay Jayavaram Department of Pharmacology, Siddha Central Research Institute, Central Council for Research in Siddha, Anna Hospital Campus, Arumbakkam, Chennai, Tamilnadu, India.
  • Dayanand Reddy Gaddam Department of Pharmacology, Siddha Central Research Institute, Central Council for Research in Siddha, Anna Hospital Campus, Arumbakkam, Chennai, Tamilnadu, India.
  • Vijay Narasimha Kumar Godlaveti Department of Pharmacology, Dr. Anjali Chatterjee Regional Research Institute for Homeopathy, Central Council for Research in Homeopathy, Kolkata, West Bengal, India.
  • Pullaiah Chitikela Department of Pharmacology, Siddha Central Research Institute, Central Council for Research in Siddha, Anna Hospital Campus, Arumbakkam, Chennai, Tamilnadu, India.
  • Vara Prasad Saka Department of Pharmacology, Dr. Anjali Chatterjee Regional Research Institute for Homeopathy, Central Council for Research in Homeopathy, Kolkata, West Bengal, India.

Stress is the body’s reaction to any kind of injury or danger. It is linked to the production of oxidative free radicals, which are responsible for a variety of acute, chronic, and potentially fatal illnesses and diseases. Free radicals, due to their extreme reactivity, can harm or even kill cells. A High-Fat Diet (HFD) causes “oxidative stress”, which is characterized by an increase in the body’s generation of Reactive Oxygen Species (ROS) as a result of higher levels of triglycerides and Free Fatty Acids (FFA). HFD-induced oxidative stress alters cellular function by affecting transcriptional factors and mitochondrial enzymes (synthesis/inhibition). ROS and FFA damage the receptors of the epithelium, resulting in epithelial damage that impairs cellular function. ROS levels can harm cells by altering the expression of microRNA (miRNA), a sign of RNA damage. MiRNAs are non-coding RNAs found in animals, plants, and some viruses that play a role in the post-transcriptional regulation of gene expression. These three pathways—RNA cleavage, RNA destabilization, and RNA translation into proteins— all play a role in mRNA expression. The miRNA regulates the up- and downregulation of mRNA expression for cellular function, enzyme synthesis, and receptor modulation. MiRNA regulates cell function by maintaining the balance between cellular ROS levels and cellular damage.


Kresge N, Simoni RD, Hill RL. The ATP Requirement for fatty acid oxidation: the early work of Albert L. Lehninger. J Biol Chem 2005;280:e11–e12. DOI: https://doi.org/10.1016/S0021-9258(19)60522-3

Trindade de Paula M, Poetini Silva MR, Machado Araujo S, et al. High-fat diet induces oxidative stress and MPK2 and HSP83 gene expression in drosophila melanogaster. Oxid Med Cell Longev 2016;2016:4018157. DOI: https://doi.org/10.1155/2016/4018157

Wahid F, Shehzad A, Khan T, Kim YY. MicroRNAs: Synthesis, mechanism, function, and recent clinical trials. Biochim Biophys Acta - Mol Cell Res 2010;1803:1231–43. DOI: https://doi.org/10.1016/j.bbamcr.2010.06.013

Kesh SB, Sarkar D, Manna K. High-fat diet-induced oxidative stress and its impact on metabolic syndrome: A review. Asian J Pharm Clin Res 2016;9:38–43.

Le Lay S, Simard G, Martinez MC, Andriantsitohaina R. Oxidative stress and metabolic pathologies: From an adipocentric point of view. Oxid Med Cell Longev 2014;2014:908539. DOI: https://doi.org/10.1155/2014/908539

Kim YJ, Hwang SH, Cho HH, et al. MicroRNA 21 regulates the proliferation of human adipose tissue-derived mesenchymal stem cells and high-fat diet-induced obesity alters microRNA 21 expression in white adipose tissues. J Cell Physiol 2012;227:183–93. DOI: https://doi.org/10.1002/jcp.22716

Gharanei S, Shabir K, Brown JE, et al. Regulatory microRNAs in brown, brite and white adipose tissue. Cells 2020;9:2489. DOI: https://doi.org/10.3390/cells9112489

Goto T, Lee JY, Teraminami A, et al. Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes. J Lipid Res 2011;52:873–84. DOI: https://doi.org/10.1194/jlr.M011320

Zhao Y, Xiang L, Liu Y, et al. Atherosclerosis induced by a high-cholesterol and high-fat diet in the inbred strain of the wuzhishan miniature pig. Anim Biotechnol 2018;29:110-8. DOI: https://doi.org/10.1080/10495398.2017.1322974

Yu D, Chen G, Pan M, et al. High fat diet-induced oxidative stress blocks hepatocyte nuclear factor 4α and leads to hepatic steatosis in mice. J Cell Physiol 2018;233:4770–82. DOI: https://doi.org/10.1002/jcp.26270

Wilson RA, Deasy W, Hayes A, Cooke MB. High fat diet and associated changes in the expression of micro-RNAs in tissue: Lessons learned from animal studies. Mol Nutr Food Res 2017;61. DOI: https://doi.org/10.1002/mnfr.201600943

Berglund L. Lipid biochemistry: An introduction. Am J Clin Nutr 2003;78:353-4. DOI: https://doi.org/10.1093/ajcn/78.2.353a

Craft S, Baker LD, Montine TJ, et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: A pilot clinical trial. Arch Neurol 2012;69:29–38. DOI: https://doi.org/10.1001/archneurol.2011.233

Ilkun O, Boudina S. Cardiac dysfunction and oxidative stress in the metabolic syndrome: an update on antioxidant therapies. Curr Pharm Des 2013;19:4806–17. DOI: https://doi.org/10.2174/1381612811319270003

Zhu J, Chen T, Yang L, et al. Regulation of MicroRNA-155 in atherosclerotic inflammatory responses by targeting MAP3K10. PLoS One 2012;7:46551. DOI: https://doi.org/10.1371/journal.pone.0046551

Schimanski CC, Frerichs K, Rahman F, et al. High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells. World J Gastroenterol 2009;15:2089–2096. DOI: https://doi.org/10.3748/wjg.15.2089

Arany I, Hall S, Reed DK, et al. Nicotine enhances high-fat diet-induced oxidative stress in the kidney. Nicotine Tob Res 2016;18:1628–34. DOI: https://doi.org/10.1093/ntr/ntw029

Roden M, Price TB, Perseghin G, et al. Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 1996;97:2859–65. DOI: https://doi.org/10.1172/JCI118742

La Favor JD, Anderson EJ, Hickner RC, Wingard CJ. Erectile dysfunction precedes coronary artery endothelial dysfunction in rats fed a high-fat, high-sucrose, western pattern diet. J Sex Med 2013;10:694–703. DOI: https://doi.org/10.1111/jsm.12001

Schulz MD, Atay Ç, Heringer J, et al. High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity. Nature 2014;514:508–512. DOI: https://doi.org/10.1038/nature13398

Freeman LR, Haley-Zitlin V, Rosenberger DS, Granholm AC. Damaging effects of a high-fat diet to the brain and cognition: A review of proposed mechanisms. Nutr Neurosci 2014;17:241–51. DOI: https://doi.org/10.1179/1476830513Y.0000000092

Kuwabara Y, Horie T, Baba O, et al. MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway. Circ Res 2015;116:279–88. DOI: https://doi.org/10.1161/CIRCRESAHA.116.304707

Ahn J, Lee H, Jung CH, Ha T. Lycopene inhibits hepatic steatosis via microRNA-21-induced downregulation of fatty acid-binding protein 7 in mice fed a high-fat diet. Mol Nutr Food Res 2012;56:1665–74. DOI: https://doi.org/10.1002/mnfr.201200182

Barbery CE, Celigoj FA, Turner SD, et al. Alterations in microRNA expression in a murine model of diet-induced vasculogenic erectile dysfunction. J Sex Med 2015;12:621–30. DOI: https://doi.org/10.1111/jsm.12793

Takanabe R, Ono K, Abe Y, et al. Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet. Biochem Biophys Res Commun 2008;376:728–32. DOI: https://doi.org/10.1016/j.bbrc.2008.09.050

Chartoumpekis DV, Zaravinos A, Ziros PG, et al. Differential expression of microRNAs in adipose tissue after long-term high-fat diet-induced obesity in mice. PLoS One 2012;7:34872. DOI: https://doi.org/10.1371/journal.pone.0034872

Jayavaram, M. V., Gaddam, D. R., Godlaveti, V. N. K., Chitikela, P., & Saka, V. P. (2023). The impact of high-fat diet-induced oxidative stress on micro RNA’s in various tissues. Pre-Clinical Research, 1(1). https://doi.org/10.4081/pcr.2023.9529

Downloads

Download data is not yet available.

Citations