Versatile electrical stimulator for providing cardiac-like electrical impulses in vitro


Published: 14 February 2020
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Authors

  • Stefano Gabetti PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy; Interuniversity Center for the Promotion of the 3Rs Principles in Teaching and Research, Italy, Italy.
  • Giovanni Putame PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin; Interuniversity Center for the promotion of the 3Rs principles in teaching and research, Italy.
  • Federica Montrone PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin; Interuniversity Center for the promotion of the 3Rs principles in teaching and research, Italy.
  • Giuseppe Isu Department of Surgery and Department of Biomedicine, Basel University Hospital, Basel, Switzerland.
  • Anna Marsano Department of Surgery and Department of Biomedicine, Basel University Hospital, Basel, Switzerland.
  • Alberto Audenino PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin; Interuniversity Center for the promotion of the 3Rs principles in teaching and research, Italy.
  • Diana Massai PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin; Interuniversity Center for the promotion of the 3Rs principles in teaching and research, Italy.

In the perspective of reliable methods alternative to in vivo animal testing for cardiac tissue engineering (CTE) research, the versatile electrical stimulator ELETTRA has been developed. ELETTRA delivers controlled and stable cardiac-like electrical impulses, and it can be coupled to already existing bioreactors for providing in vitro combined biomimetic culture conditions. Designed to be cost-effective and easy to use, this device could contribute to the reduction and replacement of in vivo animal experiments in CTE.


Gabetti, S., Putame, G., Montrone, F., Isu, G., Marsano, A., Audenino, A., & Massai, D. (2020). Versatile electrical stimulator for providing cardiac-like electrical impulses in vitro. Biomedical Science and Engineering, 1(1). https://doi.org/10.4081/bse.111

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