Vitamin B group levels and supplementations in dermatology


Published: 6 July 2022
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Irregularities of vitamin levels are being increasingly identified associated with skin conditions, and systemic and topical therapies have shown promising improvements. There have been some remarkable improvements achieved, but large variations in outcomes suggest that these conditions are not simply related to a single deficiency or solved by providing a single supplement. Cyanocobalamin, pyridoxine (B6) and riboflavin (B2) supplementation were linked with exacerbating existing acne. There were also reports of allergic reactions to parenteral cobalamin including acne, rosacea, allergic site reactions or anaphylaxis with cobalamin injections. This was also reported in patients who had allergic contact dermatitis to cobalt, where cobalamin therapy resulted in cutaneous manifestations such as chronic vesicular hand dermatitis, cheilitis and stomatitis. The use of niacinamide in acne vulgaris as an alternative to clindamycin or adjunct is also notable, as well as its application for hyperpigmentation. Vitamin B3 also has promise in chemoprevention in particular non-melanoma skin cancer prophylaxis. Folic acid has a developing role in psoriasis. The data for vitiligo remains inconclusive. Assessment for potential vitamin deficiency, particularly B vitamins, should form part of the normal work-up for a wide range of skin conditions.


World Health Organisation. Micronutrients. Geneva, Switzerland: World Health Organisation; 2022. Available from: https://www.who.int/health-topics/micronutrients#tab=tab_1 Accessedon on: 12/02/2022.

Davis DR, Epp MD, Riordan HD. Changes in USDA food composition data for 43 garden crops, 1950 to 1999. J Am Coll Nutr 2004;23:669-82.

Wong J. The claim that our food is becoming less nutritious is overblown. New Scientist 22 January 2020. Available from: https://www.newscientist.com/article/mg24532661-700-the-claim-that-our-food-is-becoming-less-nutritious-is-overblown/

Coerdt KM, Goggins CA, Khachemoune A. Vitamins A, B, C, and D: a short review for the dermatologist. Altern Ther Health Med 2021;27:41-49.

Dattola A, Silvestri M, Bennardo L, et al. Role of vitamins in skin health: a systematic review. Curr Nutr Rep 2020;9:226-35.

Peechakara BV, Gupta M. Vitamin B3. Statpearls Internet. Treasure Island, FL: Statpearls Publishing; 2021.

Knip M, Douek IF, Moore WP, et al. Safety of high-dose nicotinamide: a review. Diabetologia 2000;43:1337-45.

Chen L, Hu JY, Wang SQ. The role of antioxidants in photoprotection: a critical review. J Am Acad Dermatol 2012;67:1013-24.

Forbat E, Al-Niaimi F, Ali FR. Use of nicotinamide in dermatology. Clin Exp Dermatol 2017;42:137-44.

Surjana D, Halliday GM, Martin AJ, et al. Oral nicotinamide reduces actinic keratoses in phase II double-blinded randomized controlled trials. J Invest Dermatol 2012;132:1497-500.

Chen AC, Martin AJ, Choy B, et al. A phase 3 randomized trial of nicotinamide for skin-cancer chemoprevention. N Engl J Med 2015;373:1618-26.

Rovito HA, Oblong JE. Nicotinamide preferentially protects glycolysis in dermal fibroblasts under oxidative stress conditions. Br J Dermatol 2013;169:15-24.

Fivenson DP, Breneman DL, Rosen GB, et al. Nicotinamide and tetracycline therapy of bullous pemphigoid. Arch Dermatol 1994;130:753-8.

Kolbach DN, Remme JJ, Bos WH, et al. Bullous pemphigoid successfully controlled by tetracycline and nicotinamide. Br J Dermatol 1995;133:88-90.

Honl BA, Elston DM. Autoimmune bullous eruption localized to a breast reconstruction site: response to niacinamide. Cutis 1998;62:85-6.

Sitohang IBS, Yahya YF, Simanungkalit R, et al. Efficacy and tolerability of topical nicotinamide plus antibacterial adhesive agents and zinc-pyrrolidone carboxylic acid versus placebo as an adjuvant treatment for moderate acne vulgaris in indonesia: a multicenter, double-blind, randomized, controlled trial. J Clin Aesthet Dermatol 2020;13:27-31.

Draelos ZD, Matsubara A, Smiles K. The effect of 2% niacinamide on facial sebum production. J Cosmet Laser Ther 2006;8:96-101.

Weltert Y, Chartier S, Gibaud C, et al. Double-blind clinical assessment of the efficacy of a 4% nicotinamide gel (Exfoliac® NC Gel) versus a 4% erythromycin gel in the treatment of moderate acne with a predominant inflammatory component. Nouvelles dermatologiques 2004;23:385-94.

Niren NM, Torok HM. The nicomide improvement in clinical outcomes study (NICOS): results of an 8-week trial. Cutis 2006;77:17-28.

Shalita AR, Smith JG, Parish LC, et al. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. Int J Dermatol 1995;34:434-7.

Ragunatha S, Jagannath KV, Murugesh SB, Ramesh M, et al. Therapeutic response of vitamin A, vitamin B complex, essential fatty acids and vitamin E in the treatment of phrynoderma: a randomized controlled study. J Clin Diagn Res 2014;8:116-8.

Navarrete-Solís J, Castanedo-Cázares JP, Torres-Álvarez B, et al. A double-blind, randomized clinical trial of niacinamide 4% versus hydroquinone 4% in the treatment of melasma. Dermatol Res Pract 2011;379173.

Kimball AB, Kaczvinsky JR, Li J, et al. Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial. Br J Dermatol 2010;162:435-41.

Crook MA. The importance of recognizing pellagra (niacin deficiency) as it still occurs. Nutrition 2014;30:729-30.

Brown MJ, Ameer MA, Beier K. Vitamin B6 deficiency (pyridoxine). Statpearls Internet. Treasure Island, FL: Statpearls Publishing; 2019.

Porter KR, Tucker JB. The Ground Substance of the Living Cell. Sci Am 1981;244:56-67.

Stone OJ. Pyridoxine deficiency and antagonism produce increased ground substance viscosity with resulting seborrheic dermatitis and increased tumor resistance. Med Hypotheses 1989;30:277-80.

Inubushi T, Takasawa T, Tuboi Y, et al. Changes of glucose metabolism and skin-collagen neogenesis in vitamin B6 deficiency. Biofactors 2005;23:59-67.

Kunimoto R, Jimbow K, Tanimura A, et al. SIRT1 regulates lamellipodium extension and migration of melanoma cells. J Invest Dermatol 2014;134:1693-700.

Lipner SR. Rethinking biotin therapy for hair, nail, and skin disorders. J Am Acad Dermatol 2018;78:1236-38.

Shulpekova Y, Nechaev V, Kardasheva S, et al. The concept of folic acid in health and disease. Molecules 2021;26:3731.

Lin X, Meng X, Song Z. Homocysteine and psoriasis. Biosci Rep 2019;39:BSR20190867.

Cakmak SK, Gül U, Kiliç C, et al. Homocysteine, vitamin B12 and folic acid levels in psoriasis patients. J Eur Acad Dermatol Venereol 2009;23:300-3.

Moretti R, Caruso P. The controversial role of homocysteine in neurology: from labs to clinical practice. Int J Mol Sci 2019;20:231.

Tsai TY, Yen H, Huang YC. Serum homocysteine, folate and vitamin B12 levels in patients with psoriasis: a systematic review and meta-analysis. Br J Dermatol 2019;180:382-89.

Stabler SP. Vitamin B12 deficiency. N Engl J Med 2013;368:149-60.

Gille D, Schmid A. Vitamin B12 in meat and dairy products. Nutr Rev 2015;73:106-15.

Smith AD, Warren MJ, Refsum H. Vitamin B12. Adv Food Nutr Res 2018;83:215-79.

Brescoll J, Daveluy S. A review of vitamin B12 in dermatology. Am J Clin Dermatol 2015;16:27-33.

Leiferman KM, Gleich GJ, Peters MS. Dermatologic manifestations of the hypereosinophilic syndromes. Immunol Allergy Clin North Am 2007;27:415-41.

Srivastava N, Chand S, Bansal M, et al. Reversible hyperpigmentation as the first manifestation of dietary vitamin B12 deficiency. Indian J Dermatol Venereol Leprol 2006;72:389-90.

Den Elzen WP, Groeneveld Y, De Ruijter W, et al. Long-term use of proton pump inhibitors and vitamin B12 status in elderly individuals. Aliment Pharmacol Ther. 2008;27:491-7.

Aaron S, Kumar S, Vijayan J, et al. Clinical and laboratory features and response to treatment in patients presenting with vitamin B12 deficiency-related neurological syndromes. Neurol India 2005;53:55-9.

Volkov I, Rudoy I, Freud T, et al. Effectiveness of vitamin B12 in treating recurrent aphthous stomatitis: a randomized, double-blind, placebo-controlled trial. J Am Board Fam Med 2009;22:9-16.

Karadag AS, Tutal E, Ertugrul DT, Akin KO. Effect of isotretinoin treatment on plasma holotranscobalamin, vitamin B12, folic acid, and homocysteine levels: non-controlled study. Int J Dermatol 2011;50:1564-9.

Yamashiki M, Nishimura A, Kosaka Y. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol 1992;37:173-82.

Stücker M, Pieck C, Stoerb C, et al. Topical vitamin B12--a new therapeutic approach in atopic dermatitis-evaluation of efficacy and tolerability in a randomized placebo-controlled multicentre clinical trial. Br J Dermatol 2004;150:977-83.

Jung SH, Cho YS, Jun SS, et al. Topical application of liposomal cobalamin hydrogel for atopic dermatitis therapy. Pharmazie 2011;66:430-5.

Shaker OG, El-Tahlawi SM. Is there a relationship between homocysteine and vitiligo? A pilot study. Br J Dermatol. 2008;159:720-4.

Balci DD, Yonden Z, Yenin JZ, Okumus N. Serum homocysteine, folic acid and vitamin B12 levels in vitiligo. Eur J Dermatol 2009;19:382-3.

Montes LF, Diaz ML, Lajous J, Garcia NJ. Folic acid and vitamin B12 in vitiligo: a nutritional approach. Cutis 1992;50:39-42.

Tjioe M, Gerritsen MJ, Juhlin L, van de Kerkhof PC. Treatment of vitiligo vulgaris with narrow band UVB (311 nm) for one year and the effect of addition of folic acid and vitamin B12. Acta Derm Venereol 2002;82:369-72.

Dupré A, Albarel N, Bonafe JL, et al. Vitamin B-12 induced acnes. Cutis 1979;24:210-1.

Bilwani F, Adil SN, Sheikh U, et al. Anaphylactic reaction after intramuscular injection of cyanocobalamin (vitamin B12): a case report. J Pak Med Assoc 2005;55:217-9.

Price ML, MacDonald DM. Cheilitis and cobalt allergy related to ingestion of vitamin B12. Contact Dermatitis 1981;7:352.

Clare CE, Brassington AH, Kwong WY, Sinclair KD. One-carbon metabolism: linking nutritional biochemistry to epigenetic programming of long-term development. Annu Rev Anim Biosci 2019;7:263-87.

Depeint F, Bruce WR, Shangari N, et al. Mitochondrial function and toxicity: role of B vitamins on the one-carbon transfer pathways. Chem Biol Interact 2006;163:113-32.

Sies H. Oxidative stress: concept and some practical aspects. Antioxidants 2020;9:852.

Olorunnisola OS, Okeleji LO, Oladipo AA, et al. Vitamins as Antioxidants. J Food Sci Nutr Res 2019;2:214-35.

Moat SJ, Ashfield-Watt PA, Powers HJ, et al. Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR (C677T) genotype. Clin Chem 2003;49:295-302.

Bolisetty S, Naidoo D, Lui K, et al. Antenatal supplementation of antioxidant vitamins to reduce the oxidative stress at delivery—a pilot study. Early Hum Dev 2002;67:47-53.

Tan BL, Norhaizan ME, Liew WPP, Sulaiman Rahman H. Antioxidant and oxidative stress: a mutual interplay in age-related diseases. Front Pharmacol 2018;9:1162.

Murer SB, Aeberli I, Braegger CP, et al. Antioxidant supplements reduced oxidative stress and stabilized liver function tests but did not reduce inflammation in a randomized controlled trial in obese children and adolescents. J Nutrition 2014;144:193-201.

Sharifi-Rad M, Anil Kumar NV, Zucca P, et al. Lifestyle, oxidative stress, and antioxidants: back and forth in the pathophysiology of chronic diseases. Front Physiol 2020;11:694-94.

Chen F, Du M, Blumberg JB, et al. Association among dietary supplement use, nutrient intake, and mortality among U.S. adults. Ann Intern Med 2019;170:604-13.

Elgharably, N., Al Abadie, M., Al Abadie, M., Ball, P. A., & Morrissey, H. (2022). Vitamin B group levels and supplementations in dermatology. Dermatology Reports, 15(1). https://doi.org/10.4081/dr.2022.9511

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