Erosive pustular dermatosis of the scalp: a pathogenetic mystery and therapeutic challenge
https://doi.org/10.4081/dr.2022.9556
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rosive pustular dermatosis of the scalp (EPD) is a rare condition that affects pre- dominantly the adult population and occurs on a previously photo-damaged bald scalp. The physical examination is presented with large erythematous, erosive and crusted patches with granulation on an atrophic skin. The problem in patients with erosive pustular dermatosis of the scalp arises from the non-specific clinical and histopatholog- ical findings, which can be misleading. Biopsy followed by careful histopathologi- cal verification is mandatory, although the finding is nonspecific. The histopathology findings are characterized by superficial erosions with mild neutrophil infiltrate, mainly intravascular and focally with neu- trophil exocytosis. Focal parakeratosis, smoothed rete ridges without pronounced interface changes. Pronounced lymphoplas- macytic infiltrate with focal distribution in the dermis, giant cell reaction with the for- mation of a “foreign body” granuloma. We report a 58-year-old male patient with a 1- year-old lesion, suspected for skin cancer, later diagnosed with EPDS, which was suc- cessfully treated with topical clobetasol proprionate after 3-5weeks.
Michelerio A, Vassallo C, Fiandrino G, Tomasini CF. Erosive pustular dermatosis of the scalp: a clinicopathologic study of fifty cases. Dermatopathology 2021;8:450-62.
Semkova K, Tchernev G, Wollina U. Erosive pustular dermatosis (chronic atrophic dermatosis of the scalp and extremities). Clin Cosmet Investig Dermatol 2013;6:177-82.
Pye RJ, Peachey RD, Burton JL. Erosive pustular dermatosis of the scalp. Br J Dermatol 1979;100:559-66.
Starace M, Loi C, Bruni F, et al. Erosive pustular dermatosis of the scalp: clinical, trichoscopic, and histopathologic features of 20 cases. J Am Acad Dermatol 2017;76:1109-14.e2.
Okuno S, Hashimoto T, Matsuo S, Satoh T. Erosive pustular dermatosis of the scalp-like eruption from panitumumab. Australas J Dermatol 2022;63:271-2.
Vaccaro M, Di Bartolomeo L, Campitiello A, Borgia F. Erosive pustular dermatosis of the scalp following topical oxygen therapy. J Cosmet Dermatol 2022;21:403-4.
Madray VM, Kent SM, Davis LS. Aminolevulinic acid photodynamic therapy-induced erosive pustular dermatosis of the scalp. Dermatol Surg 2021;47:1140-42.
Nazzaro G, Giacalone S, Bortoluzzi P, et al. Erosive pustular dermatosis of the scalp induced by gefitinib: case and review of the literature. Dermatol Online J 2021;27:13030.
Maglie R, Antiga E. Nivolumab-induced erosive pustular dermatosis of the scalp. Int J Dermatol 2020;59:e399-e400.
Khanna U, Semsarzadeh N, Glaser K, Fernandez AP. Erosive pustular dermatosis of the scalp associated with Sirolimus. J Eur Acad Dermatol Venereol 2020;34:e15-e16.
Giuffrida R, Borgia F, Cannavò SP. Two cases of erosive pustular dermatosis of the scalp occurring after topical 3.75% imiquimod for actinic keratoses. Dermatol Ther 2019;32:e12770.
Brambilla L, Tourlaki A, Nazzaro G. Erosive pustular dermatosis of the scalp induced by ingenol mebutate. G Ital Dermatol Venereol 2018;153:743-745.
Vaccaro M, Barbuzza O, Borgia F, Cannavò SP. Erosive pustular dermatosis of the scalp following topical latanoprost for androgenetic alopecia. Dermatol Ther 2015;28:65-7.
Vaccaro M, Di Bartolomeo L, Guarneri F, Borgia F. Erosive pustular dermatosis of the scalp as local complication of trichotillomania. J Cosmet Dermatol 2022;21:4082-4083
Güder H, Güder S, Yıldırım Ş. Erosive pustular dermatosis after herpes zoster. Health Sci Rep 2021;4:e277.
Wolff H, Flaig MJ. Posttraumatische erosive pustulöse Dermatose am Kapillitium bei einer jungen Frau [Posttraumatic erosive pustular dermatosis on the scalp of a young woman]. Hautarzt 2020 Jul;71(Suppl 1):27-29. [In German]
Williams NM, Abrouk M, Kerdel FA, Kirsner RS. Erosive pustular dermatosis after CO2 laser resurfacing in mother and daughter. Dermatol Ther 2020;33:e14306.
Shahmoradi Z, Abtahi-Naeini B, Pourazizi M. Erosive pustular dermatosis of the scalp following hair transplantation. Adv Biomed Res 2014;3:176.
Negbenebor NA, Shayegan LH, Cohen LM, Kroumpouzos G. Nonmelanoma skin cancer in the setting of erosive pustular dermatosis of the scalp: a case series and comment on management implications. Dermatol Ther 2022;35:e15584.
Barilla S, Malviya N, Wang H, Sharon VR. Squamous cell carcinoma arising in chronic erosive pustular dermatosis. Dermatol Surg 2022;48:250-51.
Sladden C, Afford R. Erosive pustular dermatosis. CMAJ 2019;191:E667.
Di Altobrando A, Tabanelli M. Topical zinc oxide: breaking the vicious cycle of erosive pustular dermatosis of the scalp. Int J Dermatol. 2022;61:e216-e217.
Seckin D, Tekin B, Güneş P, Demirçay Z. Erosive pustular dermatosis of the leg in a young girl successfully treated with sulfasalazine and 308 nm monochromatic excimer light. Photodermatol Photoimmunol Photomed 2020;36:496-98.
Jaller JA, Borda LJ, Kirsner RS. Erosive pustular dermatosis of the leg successfully treated with an oral retinoid and a bi-layered skin substitute. J Drugs Dermatol 2019;18:301-302.
Uva L, Aphale AN, Kehdy J, Benedetto AV. Erosive pustular dermatosis successfully treated with a novel silicone gel. Int J Dermatol 2016;55:89-91.
Jankowski M, Skrzeczko-Kwela E, Czajkowski R. Erosive pustular dermatosis of the scalp treated with 0.1% mometasone furoate cream. Acta Dermatovenerol Croat 2014;22:67-9.
Zahdi MR, Seidel GB, Soares VC, et al. Erosive pustular dermatosis of the scalp successfully treated with oral prednisone and topical tacrolimus. An Bras Dermatol 2013;88:796-8.
Tardio NB, Daly TJ. Erosive pustular dermatosis and associated alopecia successfully treated with topical tacrolimus. J Am Acad Dermatol 2011;65:e93-e94.
Feramisco JD, Goerge T, Schulz SE, et al. Disseminated erosive pustular dermatosis also involving the mucosa: successful treatment with oral dapsone. Acta Derm Venereol 2012;92:91-2.
Darwich E, Muñoz-Santos C, Mascaró JM Jr. Erosive pustular dermatosis of the scalp responding to acitretin. Arch Dermatol 2011;147:252-3.
Meyer T, López-Navarro N, Herrera-Acosta E, et al. Erosive pustular dermatosis of the scalp: a successful treatment with photodynamic therapy. Photodermatol Photoimmunol Photomed 2010;26:44-5.
Petersen BO, Bygum A. Erosive pustular dermatosis of the scalp: a case treated successfully with isotretinoin. Acta Derm Venereol 2008;88:300-1.
Boffa MJ. Erosive pustular dermatosis of the scalp successfully treated with calcipotriol cream. Br J Dermatol 2003;148:593-5.
Ikeda M, Arata J, Isaka H. Erosive pustular dermatosis of the scalp successfully treated with oral zinc sulphate. Br J Dermatol 1982;106:742-3.
Saridakis S, Giesey RL, Ezaldein HH, Scott JF. Erosive pustular dermatosis of the scalp following surgical procedures: a systematic review. Dermatol Online J 2020;26:13030.
Eusen M, Fleuret C, Kupfer I, Fouchard F, Staroz F, Grangier Y, Plantin P. Pustulose érosive des jambes récidivant sur une greffe de peau mince [Recurrence of pustular erosive dermatosis of the leg after a skin graft]. Ann Dermatol Venereol 2012;139:224-5.
Mehmi M, Abdullah A. Erosive pustular dermatosis of the scalp occurring after partial thickness skin graft for squamous cell carcinoma. Br J Plast Surg 2004;57:806-7.
Ena P, Lissia M, Doneddu GM, Campus GV. Erosive pustular dermatosis of the scalp in skin grafts: report of three cases. Dermatology 1997;194:80-4.
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