Klinefelter syndrome and cutaneous localization of diffuse large B cell lymphoma: a real connection or a casual association?


Published: 29 August 2023
Abstract Views: 313
PDF: 213
HTML: 1
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

  • Federica Scarfì Dermatology Unit, Toscana Centro Local Health Unit, Prato Hospital; Section of Dermatology, Department of Health Sciences, University of Florence, Italy.
  • Elisabetta Magnaterra Dermatology Unit, Toscana Centro Local Health Unit, Prato Hospital; Section of Dermatology, Department of Health Sciences, University of Florence, Italy.
  • Simone Santini Hematology and Oncohematology Unit, Toscana Centro Local Health Unit, Prato Hospital, Italy.
  • Franca Taviti Dermatology Unit, Toscana Centro Local Health Unit, Prato Hospital, Italy.

Diffuse large B cell lymphoma (DLBCL) is a common aggressive subtype of non-Hodgkin lymphoma, accounting for nearly 30-40% of all cases. This condition can affect the skin both primarily and secondarily. Herein we report a clinical and dermoscopic case of skin metastasis of DLBCL in a patient with Klinefelter syndrome.


Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 2016;127:2375-90. DOI: https://doi.org/10.1182/blood-2016-01-643569

Li S, Young KH, Medeiros LJ. Diffuse large B-cell lymphoma. Pathology 2018;50:74-87. DOI: https://doi.org/10.1016/j.pathol.2017.09.006

Lanfranco F, Kamischke A, Zitzmann M, Nieschlag E. Klinefelter's syndrome. Lancet 2004;364:273-83. DOI: https://doi.org/10.1016/S0140-6736(04)16678-6

Kanakis GA, Nieschlag E. Klinefelter syndrome: more than hypogonadism. Metabolism 2018;86:135-44. DOI: https://doi.org/10.1016/j.metabol.2017.09.017

Rojas AP, Vo DV, Mwangi L, et al. Oncologic manifestations of Klinefelter syndrome. Hormones 2020;19:497-504. DOI: https://doi.org/10.1007/s42000-020-00241-7

De Sanctis V, Fiscina B, Soliman A, et al. Klinefelter syndrome and cancer: from childhood to adulthood. Pediatr Endocrinol Rev 2013;11:44-50.

Swerdlow AJ, Schoemaker MJ, Higgins CD, et al. Cancer incidence and mortality in men with Klinefelter syndrome: a cohort study. J Natl Cancer Inst 2005;97:1204-10. DOI: https://doi.org/10.1093/jnci/dji240

Ji J, Zöller B, Sundquist J, Sundquist K. Risk of solid tumors and hematological malignancy in persons with Turner and Klinefelter syndromes: a national cohort study. Int J Cancer 2016;139:754-8. DOI: https://doi.org/10.1002/ijc.30126

Hayashi Y, Eguchi M, Sugita K, et al. Cytogenetic findings and clinical features in acute leukemia and transient myeloproliferative disorder in Down's syndrome. Blood 1988;72:15-23. DOI: https://doi.org/10.1182/blood.V72.1.15.bloodjournal72115

Errichetti E, Geller S, Zalaudek I, et al. Dermatoscopy of nodular/plaque-type primary cutaneous T- and B-cell lymphomas: a retrospective comparative study with pseudolymphomas and tumoral/inflammatory mimickers by the International Dermoscopy Society. J Am Acad Dermatol 2022;86:774-81. DOI: https://doi.org/10.1016/j.jaad.2021.10.020

Sławińska M, Sokołowska-Wojdyło M, Olszewska B, et al. Dermoscopic and trichoscopic features of primary cutaneous lymphomas - systematic review. J Eur Acad Dermatol Venereol 2021;35:1470-84. DOI: https://doi.org/10.1111/jdv.17219

Scarfì, F., Magnaterra, E., Santini, S., & Taviti, F. (2023). Klinefelter syndrome and cutaneous localization of diffuse large B cell lymphoma: a real connection or a casual association?. Dermatology Reports, 16(3). https://doi.org/10.4081/dr.2023.9812

Downloads

Download data is not yet available.

Citations