Cystic folliculosebaceous hamartoma: an unusual histopathological entity: a case report


Published: 24 January 2024
Abstract Views: 156
PDF: 59
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

The skin covers our body and exhibits a complex structure that is adapted to the different body areas. The scalp skin is distinctive, and the histopathological alterations in its diseases also present distinctive features. We present the clinical case of a 28 year old female patient, with no significant medical history. She reported a nodular tumor on the left parietal region of the scalp, which had been present for 10 years and showed slow growth. The patient had no major discomfort other than an occasional discharge of scant whitish material upon applying pressure. Intralesional corticosteroids were administered but had no effect. Over the following year, the discomfort increased, leading to the decision to remove it. The anatomopathological study found dilated follicular hairy structures in the dermis filled with keratin and debris, surrounded by multiple sebaceous glands that flow there, all surrounded by a characteristic mesenchymal cells population, diagnosing a folliculosebaceous cystic hamartoma.


Kimura T, Miyazawa H, Aoyagi T, Ackerman AB. Folliculosebaceous cystic hamartoma. A distinctive malformation of the skin. Am J Dermatopathol 1991, 13, 213-20. [PMID: 1867352]. DOI: https://doi.org/10.1097/00000372-199106000-00001

Alsaad KO, Obaidat NA, Ghazarian D. Skin adnexal neoplasms—part 1: An approach to tumours of the pilosebaceous unit. J Clin Pathol 2007, 60, 129-44. DOI: https://doi.org/10.1136/jcp.2006.040337

Suarez Peñaranda JM, Vieites B, et al. Clinicopathological and immunohistochemical findings in a series of folliculosebaceous cystic hamartoma. J Cutan Pathol 2009, 36, 251-6. DOI: https://doi.org/10.1111/j.1600-0560.2008.01011.x

Ramdial PK, Chrystal V, Madaree A. Folliculosebaceous cystic hamartoma. Pathology 1998, 30, 212-214 DOI: https://doi.org/10.1080/00313029800169286

Daruish M, Ibrahim, MA. Genital Folliculosebaceous Cystic Hamartoma: A Case Report and Concise Review of the Literature. Dermatopathology 2022, 9.3: 277-281. DOI: https://doi.org/10.3390/dermatopathology9030032

Merklen Djafri C, Batard ML, Guillaume JC, et al. Folliculosebaceous cystic hamartoma: anatomo clinical study. Ann Dermatol Venereol 2012, 139, 23-30. [PMID: 22225739]. DOI: https://doi.org/10.1016/j.annder.2011.10.402

Ansai S, Kimura T, Kawana S. A clinicopathologic study of folliculosebaceous cystic hamartoma. Am J Dermatopathol 2010, 32, 815-20. [PMID: 20885285]. DOI: https://doi.org/10.1097/DAD.0b013e3181e07824

Oulee A, Cassarino D. Folliculosebaceous Cystic Hamartoma With Prominent Adipose Tissue Resembling Spindle Cell Lipoma. Am J Dermatopathol 2022; 10-1097. DOI: https://doi.org/10.1097/DAD.0000000000002236

Noh S, Kwon JE, Gil Lee K, Roh MR. Folliculosebaceous Cystic Hamartoma in a Patient with Neurofibromatosis Type I. Ann. Dermatol 2011, 23, S185–S187. DOI: https://doi.org/10.5021/ad.2011.23.S2.S185

Alegria Landa V, Jo Velasco M, Prieto Torres L, Requena L. Genital folliculo sebaceous cystic hamartoma: A claim of the stroma as a clue in the diagnosis of proliferations with follicular differentiation. J Cutan Pathol 2017, 44, 504-8. [PMID: 28211590]. DOI: https://doi.org/10.1111/cup.12920

Nguyen CM, Skupsky H, Cassarino D. Folliculosebaceous Cystic Hamartoma With Spindle Cell Lipoma Like Stromal Features. Am J Dermatopathol 2015, 37, e140-2. [PMID: 26588344]. DOI: https://doi.org/10.1097/DAD.0000000000000332

Carmen CR, Campos DM., Parra BV, Borregon NP. A giant congenital folliculosebaceous cystic hamartoma. J. Am. Acad. Dermatol 2015, 72, AB196-AB196. https://doi.org/10.1016/j.jaad.2015.02.796 DOI: https://doi.org/10.1016/j.jaad.2015.02.796

Schulz T, Hartschuh W. Folliculo sebaceous cystic hamartoma is a trichofolliculoma at its very late stage. J Cutan Pathol 1998, 25, 354-64. DOI: https://doi.org/10.1111/j.1600-0560.1998.tb01758.x

Supporting Agencies

None

Palomino Aguilar, K. S., De La Cruz Vargas, J., Latorre Zúñiga, A., Quiñones Ávila, M. del P., Urbano Rosales, L. M., & Palomino Portilla, E. A. (2024). Cystic folliculosebaceous hamartoma: an unusual histopathological entity: a case report. Dermatology Reports. https://doi.org/10.4081/dr.2024.9825

Downloads

Download data is not yet available.

Citations