Gemcitabine, a rare cause of chemotherapy-related reticulate hyperpigmentation
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Reticulate pigmentary disorders can be classified into inherited or acquired and cutaneous drug- induced reticulate hyperpigmentation belongs to this last group. The list of the drugs involved is constantly increasing and chemotherapy agents are frequently implicated. We report a new case of chemotherapy-related reticulate hyperpigmentation to gemcitabine, even though a previous chemotherapy with nanoparticle, albumin-bound (Nab®) paclitaxel and gemcitabine may have promoted the onset of the disease. Reassurance of the patients is important in these cases, in order to continue the chemotherapy, and gradual fading of the hyperpigmentation is usually observed, as in our case.
Sibaud V, Fricain JC, Baran R, Robert C. Anomalies pigmentaires induites par les traitements anticancéreux. Première partie : les chimiothérapies [Pigmentary disorders induced by anticancer agents. part I: chemotherapy]. Ann Dermatol Venereol. 2013; 140 (3): 183-96. DOI: https://doi.org/10.1016/j.annder.2012.12.012
Masson Regnault M, Gadaud N, Boulinguez S, Tournier E, Lamant L, Gladieff L, Roche H, Guenounou S, Recher C, Sibaud V. Chemotherapy-Related Reticulate Hyperpigmentation: A Case Series and Review of the Literature. Dermatology. 2015; 231 (4): 312-8. DOI: https://doi.org/10.1159/000439047
Puri PK, Lountzis NI, Tyler W, Ferringer T. Hydroxychloroquine-induced hyperpigmentation: the staining pattern. J Cutan Pathol. 2008 Dec; 35 (12): 1134-7. DOI: https://doi.org/10.1111/j.1600-0560.2008.01004.x
Sanke S, Mendiratta V, Jassi R, Yadav J, Chander R. Rituximab induced reticulate pigmentation over face in pemphigus vulgaris. Dermatol Ther. 2020 Jul; 33 (4): e13752. DOI: https://doi.org/10.1111/dth.13752
Cohen PR. Paclitaxel-associated reticulate hyperpigmentation: Report and review of chemotherapy-induced reticulate hyperpigmentation. World J Clin Cases. 2016 Dec 16; 4 (12): 390-400. DOI: https://doi.org/10.12998/wjcc.v4.i12.390
Necessary CA, Roffwarg D, Ellis D. Reticulated hyperpigmentation following chemotherapy for radiation-induced osteosarcoma. J Am Acad Dermatol. 2014 Jul; 71 (1): e23-4. DOI: https://doi.org/10.1016/j.jaad.2013.12.017
Youssef M, Mokni S, Belhadjali H, Aouem K, Moussa A, Laatiri A, Zili J. Cyclophosphamide-induced generalised reticulated skin pigmentation: a rare presentation. Int J Clin Pharm. 2013 Jun;35 (3): 309-12. DOI: https://doi.org/10.1007/s11096-013-9756-1
Kumar S, Bhattacharjee R, Kambhampati SBN, Narang T, Kanwar AJ, Vinay K. Chemotherapy-induced reticulate pigmentation in three Indian patients including a case in the pediatric age group. Indian J Dermatol Venereol Leprol. 2021; 87 (3): 386-388. DOI: https://doi.org/10.25259/IJDVL_216_20
Allen BJ, Parker D, Wright AL. Reticulate pigmentation due to 5-fluorouracil. Int J Dermatol. 1995 Mar; 34 (3): 219-20. DOI: https://doi.org/10.1111/j.1365-4362.1995.tb01579.x
Jogi R, Garman M, Pielop J, Orengo I, Hsu S. Reticulate Hyperpigmentation secondary to 5-fluorouracil and idarubicin. J Drugs Dermatol. 2005 Sep-Oct; 4 (5): 652-6.
Wright AL, Bleehen SS, Champion AE. Reticulate pigmentation due to bleomycin: light- and electron-microscopic studies. Dermatologica. 1990; 180 (4): 255-7. DOI: https://doi.org/10.1159/000248042
Kang D, Kim N, Im YH, Park YH, Kim JY, Park H, Kim E, Zhao D, Guallar E, Ahn JS, Cho J. Efficacy of a tailored moisturizer for reducing chemotherapy-induced skin dryness in breast cancer patients: A randomized controlled clinical trial. J Am Acad Dermatol. 2022; 87 (4): 858-860. DOI: https://doi.org/10.1016/j.jaad.2021.10.047
Chu CH, Chou CY, Lin FL. Generalized eczema craquelé (asteatotic dermatitis) associated with pemetrexed treatment. J Eur Acad Dermatol Venereol. 2016; 30: e81-e83. DOI: https://doi.org/10.1111/jdv.13329
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