Resolution of paraneoplastic palmoplantar keratoderma after treating mixed serous neuroendocrine tumor of the pancreas: a case report and literature review
https://doi.org/10.4081/dr.2024.9906
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Palmoplantar keratodermas (PPKs), also known as ‘keratosis palmaris et plantaris’, are a heterogeneous group of disorders characterized by abnormal thickening of the epidermal skin of the palms and soles leading to hyperkeratosis. It could be acquired or hereditary. Acquired PPK often occurs as a paraneoplastic syndrome as well as a stigma of other dermatoses. We report a rare case of paraneoplastic PPK secondary to mixed neuroendocrine tumor of the pancreas with complete remission after surgical excision of the cancer.
Arnold HL. "Andrews' diseases of the skin: clinical dermatology". (No Title) (1990).
Kelsell DP, Stevens HP. The palmoplantar keratodermas: much more than palms and soles. Mol Med Today 1999;5:107-13.
Patel S, Zirwas M, English JC 3rd. Acquired palmoplantar keratoderma. Am J Clin Dermatol. 2007;8:1-11.
Cohen PR, Grossman ME, Almeida L, Kurzrock R. Tripe palms and malignancy. J Clin Oncol 1989;7:669-78.
Barman B, Devi LP, Thakur BK, Raphael V. Tripe Palms and Acanthosis Nigricans: A Clue for Diagnosis of Advanced Pancreatic Adenocarcinoma. Indian Dermatol Online J 2019;10:453-455.
McGinness J, Greer K. Malignant acanthosis nigricans and tripe palms associated with pancreatic adenocarcinoma. Cutis 2006;78:37-40.
Ulla JL, Garcia-Doval I, Posada C, et al. Plantar keratoderma as a presenting sign of pancreatic adenocarcinoma. J Clin Ultrasound 2008;36:108-9.
Pentenero M, Carrozzo M, Pagano M, Gandolfo S. Oral acanthosis nigricans, tripe palms and sign of leser-trélat in a patient with gastric adenocarcinoma. Int J Dermatol 2004;43:530-2.
Cohen PR, Grossman ME, Almeida L, Kurzrock R. Tripe palms and malignancy. J Clin Oncol 1989;7:669-78.
Jiang Y, Tsoi LC, Billi AC, et al. Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin. JCI Insight 2020;5:e142067.
Brugge WR, Lauwers GY, Sahani D, et al. Cystic neoplasms of the pancreas. N Engl J Med 2004;351:1218-26.
Zhang Z, Liu L, Li Y, et al. Therapeutic experience of a pancreatic mixed serous neuroendocrine neoplasm invading peripancreatic vessels: A case report. Medicine (Baltimore). 2022;101:e30323.
Li Y, Dai M, Chang X, et al. Mixed serous neuroendocrine neoplasm of the pancreas: Case report and literature review. Medicine (Baltimore) 2016;95:e4205.
Nießen A, Schimmack S, Weber TF, et al. Presentation and outcome of mixed neuroendocrine non-neuroendocrine neoplasms of the pancreas. Pancreatology. 2021;21:224-235.
Copyright (c) 2024 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Downloads
Citations
