Resolution of paraneoplastic palmoplantar keratoderma after treating mixed serous neuroendocrine tumor of the pancreas: a case report and literature review
https://doi.org/10.4081/dr.2024.9906
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Palmoplantar keratodermas (PPKs), also known as ‘keratosis palmaris et plantaris’, are a heterogeneous group of disorders characterized by abnormal thickening of the epidermal skin of the palms and soles leading to hyperkeratosis. It could be acquired or hereditary. Acquired PPK often occurs as a paraneoplastic syndrome as well as a stigma of other dermatoses. We report a rare case of paraneoplastic PPK secondary to mixed neuroendocrine tumor of the pancreas with complete remission after surgical excision of the cancer.
Arnold, Harry Loren, et al. "Andrews' diseases of the skin: clinical dermatology." (No Title) (1990).
Kelsell DP, Stevens HP. The palmoplantar keratodermas: much more than palms and soles. Mol Med Today. 1999 Mar;5(3):107-13. doi: 10.1016/s1357-4310(98)01428-2. PMID: 10203734. DOI: https://doi.org/10.1016/S1357-4310(98)01428-2
Patel S, Zirwas M, English JC 3rd. Acquired palmoplantar keratoderma. Am J Clin Dermatol. 2007;8(1):1-11. doi: 10.2165/00128071-200708010-00001. PMID: 17298101. DOI: https://doi.org/10.2165/00128071-200708010-00001
Cohen PR, Grossman ME, Almeida L, Kurzrock R. Tripe palms and malignancy. J Clin Oncol. 1989 May;7(5):669-78. doi: 10.1200/JCO.1989.7.5.669. PMID: 2651581.
Barman B, Devi LP, Thakur BK, Raphael V. Tripe Palms and Acanthosis Nigricans: A Clue for Diagnosis of Advanced Pancreatic Adenocarcinoma. Indian Dermatol Online J. 2019 Jul-Aug;10(4):453-455. doi: 10.4103/idoj.IDOJ_427_18. PMID: 31334069; PMCID: PMC6615400. DOI: https://doi.org/10.4103/idoj.IDOJ_427_18
McGinness J, Greer K. Malignant acanthosis nigricans and tripe palms associated with pancreatic adenocarcinoma. Cutis. 2006 Jul;78(1):37-40. PMID: 16903319.
Ulla JL, Garcia-Doval I, Posada C, Soto S, Alvarez C, Ledo L, Vazquez-Astray E. Plantar keratoderma as a presenting sign of pancreatic adenocarcinoma. J Clin Ultrasound. 2008 Feb;36(2):108-9. doi: 10.1002/jcu.20377. PMID: 17661382. DOI: https://doi.org/10.1002/jcu.20377
Pentenero M, Carrozzo M, Pagano M, Gandolfo S. Oral acanthosis nigricans, tripe palms and sign of leser-trélat in a patient with gastric adenocarcinoma. Int J Dermatol. 2004 Jul;43(7):530-2. doi: 10.1111/j.1365-4632.2004.02159.x. PMID: 15230897. DOI: https://doi.org/10.1111/j.1365-4632.2004.02159.x
Cohen PR, Grossman ME, Almeida L, Kurzrock R. Tripe palms and malignancy. J Clin Oncol. 1989 May;7(5):669-78. doi: 10.1200/JCO.1989.7.5.669. PMID: 2651581. DOI: https://doi.org/10.1200/JCO.1989.7.5.669
Jiang Y, Tsoi LC, Billi AC, Ward NL, Harms PW, Zeng C, Maverakis E, Kahlenberg JM, Gudjonsson JE. Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin. JCI Insight. 2020 Oct 15;5(20):e142067. doi: 10.1172/jci.insight.142067. PMID: 33055429; PMCID: PMC7605526. DOI: https://doi.org/10.1172/jci.insight.142067
Brugge WR, Lauwers GY, Sahani D, Fernandez-del Castillo C, Warshaw AL. Cystic neoplasms of the pancreas. N Engl J Med. 2004 Sep 16;351(12):1218-26. doi: 10.1056/NEJMra031623. PMID: 15371579. DOI: https://doi.org/10.1056/NEJMra031623
Zhang Z, Liu L, Li Y, Liu Z, Zhang C, Zhao Y, Zhu M, Wan B, Deng H, Xie X, Tian K, Guo Z, Yang H, Liao J, Zhu H, Liu L, Wang M, Ma X, Liu T, Huang N, Gao Y, Zhao J, Liao F, Li F, Wang X, Yuan R, Liu X, Chang L. Therapeutic experience of a pancreatic mixed serous neuroendocrine neoplasm invading peripancreatic vessels: A case report. Medicine (Baltimore). 2022 Sep 2;101(35):e30323. doi: 10.1097/MD.0000000000030323. PMID: 36107509; PMCID: PMC9439807. DOI: https://doi.org/10.1097/MD.0000000000030323
Li Y, Dai M, Chang X, Hu W, Chen J, Guo J, Wu W, Zhang T, Liao Q, Liu Z, Hu Y, Zhao Y. Mixed serous neuroendocrine neoplasm of the pancreas: Case report and literature review. Medicine (Baltimore). 2016 Aug;95(34):e4205. doi: 10.1097/MD.0000000000004205. PMID: 27559942; PMCID: PMC5400308. DOI: https://doi.org/10.1097/MD.0000000000004205
Nießen A, Schimmack S, Weber TF, Mayer P, Bergmann F, Hinz U, Büchler MW, Strobel O. Presentation and outcome of mixed neuroendocrine non-neuroendocrine neoplasms of the pancreas. Pancreatology. 2021 Jan;21(1):224-235. doi: 10.1016/j.pan.2020.11.020. Epub 2020 Dec 3. PMID: 33309225. DOI: https://doi.org/10.1016/j.pan.2020.11.020
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